Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Host cellular immune response to pneumococcal lung infection in mice
Autore:
Kadioglu, A; Gingles, NA; Grattan, K; Kerr, A; Mitchell, TJ; Andrew, PW;
Indirizzi:
Univ Leicester, Dept Microbiol & Immunol, Leicester LE1 9HN, Leics, England Univ Leicester Leicester Leics England LE1 9HN er LE1 9HN, Leics, England Univ Glasgow, Div Infect & Immun, Glasgow, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland & Immun, Glasgow, Lanark, Scotland
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 2, volume: 68, anno: 2000,
pagine: 492 - 501
SICI:
0019-9567(200002)68:2<492:HCIRTP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PNEUMOLYSIN-NEGATIVE MUTANT; STREPTOCOCCUS-PNEUMONIAE; CRYPTOCOCCUS-NEOFORMANS; BACTERICIDAL ACTIVITY; RESPIRATORY BURST; T-CELLS; RECRUITMENT; INHIBITION; TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Andrew, PW Univ Leicester, Dept Microbiol & Immunol, Med Sci Bldg,Univ Rd,Leicester LE1 9HN, Leics, England Univ Leicester Med Sci Bldg,Univ Rd Leicester Leics England LE1 9HN
Citazione:
A. Kadioglu et al., "Host cellular immune response to pneumococcal lung infection in mice", INFEC IMMUN, 68(2), 2000, pp. 492-501

Abstract

Although there is substantial evidence that pneumolysin is an important virulence factor in pneumococcal pneumonia, relatively little is known about how it influences cellular infiltration into the lungs. We investigated howthe inability of mutant pneumococci to produce pneumolysin altered the pattern of inflammation and cellular infiltration into the lungs. The effect on bacterial growth in the lungs also was assessed. There were three phases of growth of wild-type bacteria in the lungs: a decline followed by a rapidincrease and then stasis or decline. The absence of pneumolysin was associated with a more rapid early decline and then a much slower increase in numbers. The pattern of inflammatory-cell accumulation also had distinct stages, and the timing of these stages was influenced by the presence of pneumolysin. Neutrophils began to accumulate about 12 to 16 h after infection withwild-type pneumococci, This accumulation occurred after the early decline in pneumococcal numbers but coincided with the period of rapid growth. Following infection with pneumococci unable to make pneumolysin, neutrophil influx was slower and less intense. Coincident with the third stage of pneumococcal growth was an accumulation of T and B lymphocytes at the sites of inflammation, but the accumulation was not associated with an increase in the total number of lymphocytes In the lungs. Lymphocyte accumulation in the absence of pneumolysin occurred but was delayed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:45:55