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Titolo:
The humoral immune response to the kinetoplastid membrane protein-11 in patients with American Leishmaniasis and Chagas disease: prevalence of IgG subclasses and mapping of epitopes
Autore:
Trujillo, C; Ramirez, R; Velez, ID; Berberich, C;
Indirizzi:
Univ Antioquia, Programa Estudio & Control Enfermedades Trop, Fac Med, Medellin, Colombia Univ Antioquia Medellin Colombia ades Trop, Fac Med, Medellin, Colombia
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 3, volume: 70, anno: 1999,
pagine: 203 - 209
SICI:
0165-2478(199912)70:3<203:THIRTT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANTUM KMP-11 PROTEIN; T-CELL SUBSETS; CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; MURINE LEISHMANIASIS; INTERFERON-GAMMA; EXPRESSION; ANTIGENS; INTERLEUKIN-2; ACTIVATION;
Keywords:
KMP-11; Leishmaniasis; Chagas disease; immunglobulins; B-cell epitope;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Berberich, C Univ Antioquia, Programa Estudio & Control Enfermedades Trop,Fac Med, AA 1226, Medellin, Colombia Univ Antioquia AA 1226 Medellin Colombia Medellin, Colombia
Citazione:
C. Trujillo et al., "The humoral immune response to the kinetoplastid membrane protein-11 in patients with American Leishmaniasis and Chagas disease: prevalence of IgG subclasses and mapping of epitopes", IMMUNOL LET, 70(3), 1999, pp. 203-209

Abstract

The kinetoplastid membrane protein-11 (KMP-11) is a major target of the humoral immune response during Leishmania-infections. The majority of sera from visceral leishmaniasis, mucocutaneous leishmaniasis and even some cutaneous leishmaniasis patients contain detectable IgG antibodies against KMP-11. We also provide evidence that this protein may act as a potent antigen inT. cruzi infections, since most Chagas sera show immunological cross-reactivity. Therefore, KMP-11 cannot be used as a specific diagnostical tool forthe serodiagnosis of leishmaniasis in those regions where both, Leishmaniaand T. cruzi infections overlap geographically. When analyzing the subclass specificity of the antibody response to KMP-11 we observed the following order of reactivity: IgG1 > > IgG3 > IgG2 > IgG4, which is similiar to thatseen in crude parasite extract. The mapping of antigenic determinants by using synthetic 20-mer peptides revealed the existence of predominantly conformational epitopes in leishmaniasis, while 50% of sera from Chagas patients reacted with a particular KMP-11 peptide. These results therefore suggestthe presence of disease-specific B-cell epitopes. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 08:11:00