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Titolo:
Invasive cytotrophoblast apoptosis in pre-eclampsia
Autore:
Genbacev, O; DiFederico, E; McMaster, M; Fisher, SJ;
Indirizzi:
Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco,CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco,CA 94143 USA Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
HUMAN REPRODUCTION
, volume: 14, anno: 1999, supplemento:, 2
pagine: 59 - 66
SICI:
0268-1161(199912)14:<59:ICAIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; HUMAN CHORIONIC VILLI; ENDOVASCULAR INVASION; PLACENTAL APOPTOSIS; FIBRIN DEPOSITS; PREECLAMPSIA; PREGNANCY; BCL-2; ADHESION; DIFFERENTIATION;
Keywords:
apoptosis; Bcl-2; cytotrophoblast; placenta; pre-eclampsia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fisher, SJ Univ Calif San Francisco, Dept Stomatol, HSW 604, San Francisco, CA 94143 USA Univ Calif San Francisco HSW 604 San Francisco CA USA 94143 USA
Citazione:
O. Genbacev et al., "Invasive cytotrophoblast apoptosis in pre-eclampsia", HUM REPR, 14, 1999, pp. 59-66

Abstract

Pre-eclampsia is a serious pregnancy complication diagnosed by signs of-widespread maternal endothelial dysfunction, In normal pregnancy, a subpopulation of placental cytotrophoblast stem cells executes a differentiation programme that leads to invasion of the uterus and its vasculature, This process attaches the conceptus to the uterine wall and starts the how of maternal blood to the placenta. In pre-eclampsia, cytotrophoblasts fail to differentiate along the invasive pathway. The functional consequences of this abnormality negatively affect interstitial and endovascular invasion, thereby compromising blood flow to the maternal-fetal interface. To determine whether abnormal differentiation and/or hypoxia leads to apoptosis of invasive cytotrophoblasts, we used the TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling) method to label DNA strand breaks in tissuesections of the placenta and the uterine wall to which it attaches. Control samples (n = 9) showed little or no apoptosis in any location, but in samples from patients with pre-eclampsia, 15-50% of the cytotrophoblast subpopulation that invaded the uterine wall was labelled (8/9 samples). These same cells failed to stain for Bcl-2, a survival factor normally expressed by trophoblasts in both the placenta and the uterine wall. Our results show that pre-eclampsia is associated with widespread apoptosis of cytotrophoblasts that invade the uterus, The magnitude of programmed cell death in this population may account for the sudden onset of symptoms in some patients, as well as the associated coagulopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:21:15