Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of HLA class I-specific inhibitory receptors in human cytolyticT lymphocytes: A regulated mechanism that controls T-cell activation and function
Autore:
Mingari, MC; Ponte, M; Vitale, C; Bellomo, R; Moretta, L;
Indirizzi:
Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa, Italy Univ Genoa Genoa Italy a, Dipartimento Oncol Biol & Genet, Genoa, Italy Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy Univ Genoa GenoaItaly noa, Dipartimento Med Sperimentale, Genoa, Italy Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 1, volume: 61, anno: 2000,
pagine: 44 - 50
SICI:
0198-8859(200001)61:1<44:EOHCII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; IMMUNOGLOBULIN-SUPERFAMILY; NK CELLS; SURFACE-MOLECULE; RECOGNITION; CD94; CLONES; COMPLEX; P58; CD94/NKG2A;
Keywords:
cytolytic T lymphocytes; HLA class I; killer inhibitory receptors; NK-like activity; interleukin-15; transforming growth factor-beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Moretta, L Ctr Biotecnol Avanzate, Lab Immunopatol, Largo Rosanna Benzi 10, I-16132 Genoa, Italy Ctr Biotecnol Avanzate Largo Rosanna Benzi 10 GenoaItaly I-16132
Citazione:
M.C. Mingari et al., "Expression of HLA class I-specific inhibitory receptors in human cytolyticT lymphocytes: A regulated mechanism that controls T-cell activation and function", HUMAN IMMUN, 61(1), 2000, pp. 44-50

Abstract

Different families of major histocompatibility complex (MHC)-specific inhibitory receptors (NKRs) play a major role in natural killer (NK) cell function, allowing discrimination between normal cells and cells that do not express adequate amounts of MHC class I antigens. This occurs in most instances as a consequence of viral infection or tumor transformation. In T lymphocytes, expression of NKR is mostly confined to activated CD8(+) cytolytic T lymphocytes (CTLs). While NKR expression by CTLs may be viewed as a mechanism preventing damages to normal cells by those CTLs that have acquired NK-like activity, it may also down regulate TCR-mediated T cell activation, thus, impairing CTL functions. The finding that certain cytokines can modulatekiller inhibitory receptor expression in CTLs is of major interest and might be instrumental in novel therapeutic approaches aimed at the down regulation of T-cell function in transplantation or autoimmunity. Human Immunology 61, 44-50 (2000). (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:42:30