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Titolo:
A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes
Autore:
Kuhlenbaumer, G; Schirmacher, A; Meuleman, J; Tissir, F; Del-Favero, J; Stogbauer, F; Young, P; Ringelstein, B; Van Broeckhoven, C; Timmerman, V;
Indirizzi:
Univ Antwerp, Dept Biochem, Peripheral Neuropathy Grp,Born Bunge Fdn, Genet Mol Lab,Flanders Interuniv Inst Biotechnol, B-2610 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2610 Biotechnol, B-2610 Antwerp, Belgium Univ Munster, Dept Neurol, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 Dept Neurol, D-4400 Munster, Germany
Titolo Testata:
GENOMICS
fascicolo: 2, volume: 62, anno: 1999,
pagine: 242 - 250
SICI:
0888-7543(199912)62:2<242:ASBCAP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEREDITARY NEURALGIC AMYOTROPHY; BRACHIAL-PLEXUS NEUROPATHY; ESOPHAGEAL CANCER TOC; HUMAN GENOME; BREAST-TUMORS; ALLELIC LOSS; HUMAN DNA; REGION; DISTAL; LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Timmerman, V Univ Antwerp, Dept Biochem, Peripheral Neuropathy Grp,Born Bunge Fdn, Genet Mol Lab,Flanders Interuniv Inst Biotechnol, Univ Pl 1, B-2610 Antwerp, Belgium Univ Antwerp Univ Pl 1 Antwerp Belgium B-2610 twerp, Belgium
Citazione:
G. Kuhlenbaumer et al., "A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes", GENOMICS, 62(2), 1999, pp. 242-250

Abstract

Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant recurrent neuropathy mapped to a 4-cM interval on chromosome 17q25 between the short tandem repeat (STR) markers D17S1603 and D17S802. Chromosome 17q25 in general and the 4-cM HNA region in particular are also implicated in the pathogenesis of a number of tumors (tylosis with esophageal cancer, sporadic breastand ovarian tumors) and harbor a psoriasis susceptibility locus. Initial attempts to construct a yeast artificial chromosome contig failed. Therefore, we have now constructed a complete PI artificial chromosome (PAC) and bacterial artificial chromosome (BAC) contig of the region flanked by the STR markers D17S1603 and D17S802. The contig contains 22 PBC and 64 BAC clones and covers a physical distance of approximately 1.5 Mb. A total of 83 sequence-tagged site (STS) markers (10 known STSs and STRs, 56 STSs generated from clone end-fragments, 12 expressed sequence tags, and 5 known genes) weremapped on the contig, resulting in an extremely dense physical map with approximately 1 STS per 20 kb. This sequence-ready PAC and BAC contig will bepivotal for the positional cloning of the HNA gene as well as other disease genes mapping to this region. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:25:36