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Titolo:
Lentiviral vectors: turning a deadly foe into a therapeutic agent
Autore:
Trono, D;
Indirizzi:
Univ Geneva, Dept Genet & Microbiol, Fac Med, CMU, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 Med, CMU, CH-1211 Geneva 4, Switzerland
Titolo Testata:
GENE THERAPY
fascicolo: 1, volume: 7, anno: 2000,
pagine: 20 - 23
SICI:
0969-7128(200001)7:1<20:LVTADF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; NUCLEAR-LOCALIZATION SIGNAL; HEMATOPOIETIC STEM-CELLS; EFFICIENT GENE-TRANSFER; MURINE LEUKEMIA-VIRUS; NONDIVIDING CELLS; MATRIX PROTEIN; CYCLE ARREST; INFECTION; TRANSDUCTION;
Keywords:
lentiviral vectors; retroviral vectors; HIV; nondividing cells; in vivo gene delivery;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Trono, D Univ Geneva, Dept Genet & Microbiol, Fac Med, CMU, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland Univ Geneva 1 Rue Michel Servet Geneva Switzerland 4 Switzerland
Citazione:
D. Trono, "Lentiviral vectors: turning a deadly foe into a therapeutic agent", GENE THER, 7(1), 2000, pp. 20-23

Abstract

The past 3 years have witnessed the spectacular irruption of lentiviral vectors into the limelight of the gene therapy scene. Owing to their ability to deliver transgenes in tissues that had long appeared irremediably refractory to stable genetic manipulation, lentivectors have opened fresh perspectives for the genetic treatment of a wide array of hereditary as well as acquired disorders, and a concrete proposal for their clinical use seems imminent. This article traces the path that has led to this rapid development and describes the current stale of the art in the design and production of lentiviral vectors. The important question of biosafety is discussed. This system seems to have the edge over other gene delivery tools for particular targets, however, there remain several issues to be resolved before lentivectors make it to the bedside.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:25:04