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Titolo:
Subchronically applied phencyclidine fails to disrupt prepulse inhibition in rats
Autore:
Ehrhardt, J; Sabel, BA; Schroeder, U;
Indirizzi:
Otto Von Guericke Univ, Fac Med, Inst Med Psychol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 10, anno: 1999,
pagine: 69 - 74
SICI:
0924-977X(199912)10:1<69:SAPFTD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; SCHIZOPHRENIA; PSYCHOSIS; DOPAMINE;
Keywords:
acoustic startle; controlled release; psychosis; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Schroeder, U Otto Von Guericke Univ, Fac Med, Inst Med Psychol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
J. Ehrhardt et al., "Subchronically applied phencyclidine fails to disrupt prepulse inhibition in rats", EUR NEUROPS, 10(1), 1999, pp. 69-74

Abstract

To simulate psychosis in rats, the psychotomimetic agent phencyclidine (PCP, 5.0 mg/kg) was administered either by daily pulsatile injections or by continuous delivery with subcutaneously implanted, PCP-loaded controlled release polymers for a 5 day period. The acoustic startle response (ASR) and the prepulse inhibition (PPI) were then assessed 15 and 60 min as well as 24h after the PCP application was discontinued. An impaired PPI occurred only under the acute influence of the last PCP injection, i.e. 15 and 60 min after last PCP treatment when it had previously been given in a pulsatile manner but not when it was administered continuously. The ASR to unpaired stimuli after PCP was not modified. These findings suggest that disruption of PPI occurs only under the acute influence of PCP and that PPI deficits are not primarily the consequence of structural brain damage which PCP produces. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:48:43