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Titolo:
Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study
Autore:
Loonen, AJM; Doorschot, CH; Oostelbos, MCJM; Sitsen, JMA;
Indirizzi:
NV Organon, NL-5340 BH Oss, Netherlands NV Organon Oss Netherlands NL-5340 BH ganon, NL-5340 BH Oss, Netherlands Psychiat Hosp Reinier van Arkel, NL-5260 GB Vught, Netherlands Psychiat Hosp Reinier van Arkel Vught Netherlands NL-5260 GB Netherlands
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 10, anno: 1999,
pagine: 51 - 57
SICI:
0924-977X(199912)10:1<51:LODIBM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CATALEPSY; HALOPERIDOL; NORTRIPTYLINE; EFFICACY;
Keywords:
risperidone; mirtazapine; drug-drug interaction; antipsychotic; antidepressant; MASEAS; SADJMoD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sitsen, JMA NV Organon, Molenstr 110, NL-5340 BH Oss, Netherlands NV Organon Molenstr 110 Oss Netherlands NL-5340 BH etherlands
Citazione:
A.J.M. Loonen et al., "Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study", EUR NEUROPS, 10(1), 1999, pp. 51-57

Abstract

An open-label, non-randomized, pilot study has been performed in inpatients in need of treatment with an antipsychotic (risperidone) and an antidepressant (mirtazapine) with the objective to preliminarily assess a possible pharmacokinetic interaction and the tolerability of this combination. A 1-4-week single drug treatment phase (risperidone 1-3 mg bid or mirtazapine 30 mg nocte) was followed by a 2-4-week combined drug treatment phase at unchanged doses. Twelve patients were enrolled, nine of whom were treated with risperidone in the single drug phase. Results of plasma level measurements are available for six patients and indicate that adding mirtazapine to risperidone does not alter steady-state plasma concentrations of risperidone andits 9-hydroxy metabolite. Data from one patient suggest that adding risperidone to mirtazapine does not result in clinically relevant changes in plasma concentrations of either compound. The combination was well tolerated and no major or relevant adverse events were observed. Adding risperidone to mirtazapine probably does not necessitate a change of the dosage of either drug, but more extensive investigations are needed. (C) 1999 Elsevier Science B;V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:01:08