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Titolo:
Imaging extrastriatal dopamine D-2 receptor occupancy by endogenous dopamine in healthy humans
Autore:
Fujita, M; Verhoeff, NPLG; Varrone, A; Zoghbi, SS; Baldwin, RM; Jatlow, PA; Anderson, GM; Seibyl, JP; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, VA Connecticut, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 iat, VA Connecticut, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 d, Dept Lab Med, New Haven, CT 06510 USA Yale Univ, Dept Diagnost Radiol, VA Connecticut, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 iol, VA Connecticut, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Pharmacol, New Haven, CT 06510 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 387, anno: 2000,
pagine: 179 - 188
SICI:
0014-2999(20000110)387:2<179:IEDDRO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE BINDING; HUMAN-BRAIN; D-2-DOPAMINE RECEPTORS; NONHUMAN-PRIMATES; HIGH-AFFINITY; RAT-BRAIN; AUTORADIOGRAPHIC DISTRIBUTION; ATTENUATION CORRECTION; SYNAPTIC DOPAMINE;
Keywords:
dopamine; dopamine D-2 receptor, extrastriatal; [I-123]epidepride; SPECT (single photon emission computed tomography); alpha-methyl-para-tyrosine; schizophrenia; binding, in vivo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, M Yale Univ, Sch Med, Dept Psychiat, VA Connecticut, 116A2,950 Campbell Ave,W Haven, CT 06516 USA Yale Univ 116A2,950 Campbell Ave W Haven CTUSA 06516 06516 USA
Citazione:
M. Fujita et al., "Imaging extrastriatal dopamine D-2 receptor occupancy by endogenous dopamine in healthy humans", EUR J PHARM, 387(2), 2000, pp. 179-188

Abstract

The effect of endogenous dopamine on in vivo measurement of dopamine D-2 receptors in extrastriatal regions (thalamus and temporal cortex) was evaluated with single photon emission computed tomography and the high affinity ligand [I-123]epidepride by comparing the binding potential before and afteracute dopamine depletion. Dopamine depletion was achieved by per-oral administration of 5.5 g/70 kg body weight alpha-methyl-para-tyrosine given in 37 h. The alpha-methyl-pam tyrosine treatment increased the binding potential significantly in the temporal cortex (13 +/- 15%, P = 0.036) but not in the thalamus (2 +/- 9%). The increase of the binding potential in the temporal cortex correlated strongly with the increase of dysphoric mood evaluatedby the Positive and Negative Symptom Scale (PANSS) (rho = 0.88, P = 0.004). These results imply that [I-123]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration. (C) 2000 Elsevier Science B.V. AU rights reserved.

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Documento generato il 17/01/20 alle ore 20:24:21