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Titolo:
Dosimetry of rhenium-188 diethylene triamine penta-acetic acid for endovascular intra-balloon brachytherapy after coronary angioplasty
Autore:
Lee, J; Lee, DS; Kim, KM; Yeo, JS; Cheon, GJ; Kim, SK; Ahn, JY; Jeong, JM; Chung, JK; Lee, MC;
Indirizzi:
Seoul Natl Univ Hosp, Dept Nucl Med, Chongno Gu, Seoul 110744, South KoreaSeoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul, South Korea Seoul Natl Univ Seoul South Korea ed, Dept Nucl Med, Seoul, South Korea Seoul Natl Univ, Coll Med, Inst Radiat Med, Seoul, South Korea Seoul Natl Univ Seoul South Korea , Inst Radiat Med, Seoul, South Korea
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 27, anno: 2000,
pagine: 76 - 82
SICI:
0340-6997(200001)27:1<76:DORDTP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVERSTRETCH INJURY; REDUCE RESTENOSIS; RADIATION; IRRADIATION; ARTERIES; STENT;
Keywords:
rhenium-188 diethylene triamine penta-acetic acid; dosimetry; MIRD; endovascular brachytherapy; prevention of restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, DS Seoul Natl Univ Hosp, Dept Nucl Med, Chongno Gu, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ Hosp 28 Yongon Dong Seoul South Korea 110744 orea
Citazione:
J. Lee et al., "Dosimetry of rhenium-188 diethylene triamine penta-acetic acid for endovascular intra-balloon brachytherapy after coronary angioplasty", EUR J NUCL, 27(1), 2000, pp. 76-82

Abstract

To examine the possibility of using rhenium-188 diethylene triamine penta-acetic acid (DTPA) for endovascular intra-balloon brachytherapy after angioplasty, dose distribution around the balloon was calculated and validated by film dosimetry. Medical internal radiation dosimetry (MIRD) was calculated assuming that the balloon had ruptured and that the contents had been released into the systemic circulation. Re-188-perrhenate eluate from the W-188/Re-188 generator was concentrated using an ion column and used to label DTPA. The dose distibution around the angioplasty balloon (20 mm length, 3 mm diameter cylinder) was estimated by Monte Carlo simulation using the EGS4code. The time required for 17.6 Gy to be absorbed at 1 mm from the balloon's surface following application of 3700 MBq/ml Of Re-188 was found to be 278 s. Fifty percent of the energy was deposited in the first millimetre ofthe vessel wall from the balloon's surface. The calculated radiation absorbed dose agreed with that measured by film dosimetry, which was performed using a water phantom, with errors ranging from 9.4% to 17%. Upon balloon rupture the total amount of Re-188-DTPA was presumed to enter the systemic circulation. The resulting radiation absorbed dose was calculated using the MIRDOSE3 program and residence times obtained from dogs and amounted to 0.0056 mGy/MBq to the whole body and 4.56 mGy/MBq to the urinary bladder. The absorbed dose of 188Re-DTPA to the whole body was one-tenth of that of Re-188-perrhenate. A window-based program was developed to calculate the exposure time and the radiation dose absorbed as a function of the Re-188 concentration and the arbitrary distance from the balloon to the surrounding tissues. We conclude that Re-188-DTPA is easy to prepare, safe to use and suitable for intra-balloon brachytherapy after coronary angioplasty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:06:29