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Titolo:
Endomysial antibody production is not related to histological damage afterin vitro gluten challenge
Autore:
Biagi, F; Parnell, NDJ; Ellis, HJ; Ciclitira, PJ;
Indirizzi:
St Thomas Hosp, Rayne Inst, Gastroenterol Unit, GKT, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Unit, GKT, London SE1 7EH, England
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 1, volume: 12, anno: 2000,
pagine: 57 - 60
SICI:
0954-691X(200001)12:1<57:EAPINR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; TISSUE TRANSGLUTAMINASE; ORGAN-CULTURE; PEPTIDES; MUCOSA;
Keywords:
coeliac disease; endomysial antibodies; gliadin; tissue transglutaminase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ciclitira, PJ St Thomas Hosp, Rayne Inst, Gastroenterol Unit, GKT, LambethPalace Rd, London SE1 7EH, England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH and
Citazione:
F. Biagi et al., "Endomysial antibody production is not related to histological damage afterin vitro gluten challenge", EUR J GASTR, 12(1), 2000, pp. 57-60

Abstract

Objective To determine whether in vitro induction of endomysial antibodiesis an in vitro marker of coeliac toxicity. Design To determine whether in vitro endomysial incubation correlate with antibodies induced by gliadin histological damage induced by in vitro gliadin challenge. Methods Small-bowel organ cultures from seven patients with treated coeliac disease were incubated in an organ culture system with gliadin; histological damage was morphometrically evaluated and endomysial antibodies were measured in the organ culture supernatant by indirect immunofluorescence. Results Although incubation with gliadin caused histological damage, therewas no detectable production of endomysial antibody. Conclusions In vitro, endomysial antibody induction cannot be used as a marker of coeliac toxicity. Endomysial antibodies are not necessary for generating the histological lesion of coeliac disease. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:23:08