Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Managing antipsychotic-induced acute and chronic akathisia
Autore:
Miller, CH; Fleischhacker, WW;
Indirizzi:
Innsbruck Univ Clin, Dept Biol Psychiat, Innsbruck, Austria Innsbruck UnivClin Innsbruck Austria Biol Psychiat, Innsbruck, Austria
Titolo Testata:
DRUG SAFETY
fascicolo: 1, volume: 22, anno: 2000,
pagine: 73 - 81
SICI:
0114-5916(200001)22:1<73:MAAACA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; DRUG-INDUCED AKATHISIA; 5-HT2 ANTAGONIST RITANSERIN; TARDIVE AKATHISIA; DOUBLE-BLIND; CLINICAL CHARACTERISTICS; CLONAZEPAM TREATMENT; CONTROLLED TRIAL; PROPRANOLOL; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, CH AO Bezirkskrankenhaus Kufstein, Endach 27, A-6330 Kufstein, Austria AO Bezirkskrankenhaus Kufstein Endach 27 Kufstein Austria A-6330
Citazione:
C.H. Miller e W.W. Fleischhacker, "Managing antipsychotic-induced acute and chronic akathisia", DRUG SAFETY, 22(1), 2000, pp. 73-81

Abstract

Akathisia is a frequent and common adverse effect of treatment with antipsychotic (neuroleptic) drugs. This syndrome consists of subjective (feeling of inner restlessness and the urge to move) as well as objective components(rocking while standing or sitting, lifting feet as if marching on the spot and crossing and uncrossing the legs while sitting). Antipsychotic-induced akathisia can be classified according to the time of onset in the course of antipsychotic treatment (acute, tardive, withdrawal and chronic akathisia), Reported prevalence rates vary widely between 5 and 36.8%. Numerous risk factors for acute akathisia have been described and the exact pathophysiology of akathisia is still unknown. Since akathisia is a drug-induced adverse effect, optimal management involves its prevention rather than treatment. Standardised titration and the use of novel antipsychotics are successful measures of prevention. This paper reviews different forms of therapeutic approaches for the treatment of akathisia. Based on the available literature, propranolol or other lipophilic beta-blockers seem to be the most consistently effective treatment for acute akathisia, There is nothing in the literature to guide a clinician when treatment with beta-blockers fails. Addition of benzodiazepines would appear to be a sensible next choice, especially if subjective distresspersists. If all of these drugs are unsuccessful, amantadine or clonidine can be tried. Other agents that have been investigated include ritanserin, piracetam, valproic acid (sodium valproate) and tri-cyclic antidepressants. Evidence on the treatment of tardive akathisia is unsatisfactory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:17:40