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Titolo:
Prospective assessment of primary rectal cancer response to preoperative radiation and chemotherapy using 18-fluorodeoxyglucose positron emission tomography
Autore:
Guillem, JG; Puig-La Calle, J; Akhurst, T; Tickoo, S; Ruo, L; Minsky, BD; Gollub, MJ; Klimstra, DS; Mazumdar, M; Paty, PB; Macapinlac, H; Yeung, H; Saltz, L; Finn, RD; Erdi, Y; Humm, J; Cohen, AM; Larson, S;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Nucl Med, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Biostat & Epidemiol, New York, NY 10021USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
DISEASES OF THE COLON & RECTUM
fascicolo: 1, volume: 43, anno: 2000,
pagine: 18 - 24
SICI:
0012-3706(200001)43:1<18:PAOPRC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; F-18 FLUORODEOXYGLUCOSE; COMPUTED-TOMOGRAPHY; PET; RECURRENT; CARCINOMA; ULTRASOUND; PATTERNS; THERAPY; TUMORS;
Keywords:
rectal cancer; positron emission tomography (PET); preoperative radiation; chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Guillem, JG Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave,Room C-986, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave,RoomC-986 New York NY USA 10021
Citazione:
J.G. Guillem et al., "Prospective assessment of primary rectal cancer response to preoperative radiation and chemotherapy using 18-fluorodeoxyglucose positron emission tomography", DIS COL REC, 43(1), 2000, pp. 18-24

Abstract

PURPOSE: The purpose of this prospective study a-as to determine the ability of fluorine-18 fluorodeoxyglucose positron emission tomography to assessextent of pathologically confirmed rectal cancer response to preoperative radiation and 5-fluorouracil-based chemotherapy. METHODS: Patients with primary rectal cancer deemed eligible for preoperative radiation and 5-fluorouracil-based chemotherapy because of a clinically bulky or tethered tumor orendorectal ultrasound evidence of T3 and/or N1 were prospectively enrolled. Positron emission tomography and CT scans were obtained before preoperative radiation and 5-fluorouracil-based chemotherapy (5,040 cGy to the pelvisand 2 cycles of bolus 5-fluorouracil with leucovorin) and repeated four tofire weeks after completion of radiation and 5-fluorouracil-based chemotherapy. In addition to routine pathologic staging, detailed assessment of rectal cancer response to preoperative radiation and 5-fluorouracil-based chemotherapy was performed independently by two pathologists. Positron emissiontomography parameters studied included conventional measures such as standardized uptake value (average and maximum), positron emission tomography-derived tumor volume (size), and two novel parameters: visual response score and change in total lesion glycolysis. RESULTS: Of 21 patients enrolled, prospective data (pretreatment and posttreatment positron emission tomography, and complete pathologic assessment) were available an 15 patients. All 15demonstrated pathologic response to preoperative radiation and 5-fluorouracil-based chemotherapy. This was confirmed in 100 percent of the cases by positron emission tomography compared with 78 percent (7/9) by CT, In addition, one positron emission tomography parameter (visual response score) accurately estimated the extent of pathologic response in 60 percent (9/15) of cases compared with 22 percent (2/9) of cases with CT. CONCLUSIONS: This pilot study demonstrates that fluorine-18 fluorodeoxyglucose positron emission tomography imaging adds incremental information to the preoperative assessment of patients with rectal cancer. However, further studies in a larger series of patients are needed to verify these findings and to determine thevalue of fluorine-18 fluorodeoxyglucose positron emission tomography in a preoperative strategy aimed at identifying patients suitable for sphincter-preserving rectal cancer surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:34:09