Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gastrointestinal, genitourinary, and neurovascular disturbances in diabetes
Autore:
Vinik, A; Erbas, T; Stansberry, K;
Indirizzi:
Eastern Virginia Med Sch, Strelitz Diabet Inst, Dept Med & Pathol Anat Neurobiol, Norfolk, VA 23510 USA Eastern Virginia Med Sch Norfolk VA USA 23510 biol, Norfolk, VA 23510 USA
Titolo Testata:
DIABETES REVIEWS
fascicolo: 4, volume: 7, anno: 1999,
pagine: 358 - 378
SICI:
1066-9442(1999)7:4<358:GGANDI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER-FLOWMETER; GASTRIC MOTOR FUNCTION; NITRIC-OXIDE SYNTHASE; ERECTILE DYSFUNCTION; BLOOD-FLOW; NEUROPATHIC FOOT; MOTILITY DISORDERS; ORAL ERYTHROMYCIN; PROKINETIC AGENT; OBESE MEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Vinik, A Eastern Virginia Med Sch, Strelitz Diabet Inst, Dept Med & PatholAnat Neurobiol, Norfolk, VA 23510 USA Eastern Virginia Med Sch Norfolk VAUSA 23510 folk, VA 23510 USA
Citazione:
A. Vinik et al., "Gastrointestinal, genitourinary, and neurovascular disturbances in diabetes", DIABET REV, 7(4), 1999, pp. 358-378

Abstract

The gastrointestinal, genitourinary, and neurovascular systems are frequent targets of the autonomic complications of diabetes. Complications affecting these systems contribute greatly to the morbidity, mortality; and reduced quality of life and activities of daily living of the person with diabetes. They are also the major source of increased costs of caring for the diabetic patient, impairments range from functional disturbances related to hyper- or hypoglycemia and age, duration of diabetes, and quality of diabetes control and evolve into organic disorders with loss of parasympathetic, sympathetic, and neuropeptidergic nerves, Factors in the pathogenesis are metabolism, vascular insufficiency, loss of growth factor trophism, and autoimmune destruction of small unmyelinated nerves (C fibers) in a visceral and cutaneous distribution. The clinical manifestations range from anorexia, nausea, vomiting, brittle diabetes, diarrhea, constipation, loss of bladder control, and erectile dysfunction to impaired skin blood flow responses to heating and cooling, nociception, and gravity, with loss of amplitudes of vascular oscillation and premature aging of the neurovascular system. The disordered skin blood flow is a major factor in the development of foot ulcers and amputations. Treatments are limited to symptoms; algorithms for the many facets of these disorders are provided here? including one for gastrointestinal abnormalities and another for erectile dysfunction. Ultimately, treatment directed at the underlying pathogenic mechanisms of these manifestations is sorely needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:15:20