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Titolo:
The therapeutic potential of neurotrophins for the treatment of diabetic neuropathy
Autore:
Fernyhough, P; Tomlinson, DR;
Indirizzi:
Univ Manchester, Sch Biol Sci, Div Neurosci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
DIABETES REVIEWS
fascicolo: 4, volume: 7, anno: 1999,
pagine: 300 - 311
SICI:
1066-9442(1999)7:4<300:TTPONF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; ADULT SENSORY NEURONS; DORSAL-ROOT GANGLIA; NEUROFILAMENT GENE-EXPRESSION; FACTOR MESSENGER-RNA; RAT SCIATIC-NERVE; SUBSTANCE-P; SIGNAL-TRANSDUCTION; TRK RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Fernyhough, P Univ Manchester, Sch Biol Sci, Div Neurosci, 1-124 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester 1-124 Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
P. Fernyhough e D.R. Tomlinson, "The therapeutic potential of neurotrophins for the treatment of diabetic neuropathy", DIABET REV, 7(4), 1999, pp. 300-311

Abstract

Sensory neuron dysfunction is a hallmark of symmetrical diabetic polyneuropathy: Taken together, the clinical and pathological features of this condition give a picture of a distal degeneration, with progressive loss of sensation from both myelinated and unmyelinated primary afferents. Direct consequences of hyperglycemia, such as protein glycation and exaggerated flux through the sorbitol pathway, form one level of possible etiological components. tit the nest level-links between disordered biochemistry and neurodegeneration-a promising candidate is impaired neurotrophic support from nerve growth factor (NGF), neurotrophin-3 (NT-3), and brain-derived neurotrophic factor (BDNF). Studies focused on unmyelinated sensory fiber dysfunction in streptozocin (STZ) induced diabetic rats have established a role for deficient NGF expression in target tissues of the lower limb. The NGF-dependent (trkA-expressing) C-fiber subpopulation of unmyelinated neurons show reducedretrograde axonal transport of NGF to the lumbar dorsal root ganglia (DRG)and reduced expression of the neuropeptides substance P and calcitonin gene-related peptide (CGRP), The majority of larger myelinated sensory fibers,Which appear to be particularly sensitive to diabetes-related dysfunction?are unresponsive to NGF and do not express the trkA receptor, indeed, the available evidence indicates that these fibers express trkB and/or trkC andthat maintenance of their phenotype may depend on BDNF and/or NT-3, Recentstudies show that target tissue expression of NT-3 and BDNF is altered andretrograde axonal transport within the sciatic nerve is depressed in STZ diabetic rats. This review will discuss the current status of NGF work, withspecial reference to recent clinical trials. Also, new developments in understanding the effects of loss of NT-3 and/or BDNF dependent neurotrophic support on large myelinated sensory fiber function will be presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:36:39