Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modular regulation of cGATA-5 gene expression in the developing heart and gut
Autore:
MacNeill, C; French, R; Evans, T; Wessels, A; Burch, JBE;
Indirizzi:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Mol Biol, Bronx, NY 10461 USA Med Univ S Carolina, Cardiovasc Dev Biol Ctr, Dept Cell Biol & Anat, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 nat, Charleston, SC 29425 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 217, anno: 2000,
pagine: 62 - 76
SICI:
0012-1606(20000101)217:1<62:MROCGE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGION-SPECIFIC EXPRESSION; TISSUE-SPECIFIC ANTIGENS; TRANSCRIPTION FACTOR; SPATIAL-DISTRIBUTION; SKELETAL-MUSCLE; IMMUNOHISTOCHEMICAL ANALYSIS; MOUSE EMBRYO; CARDIAC DEVELOPMENT; CONDUCTION SYSTEM; SMOOTH-MUSCLE;
Keywords:
GATA-5; heart; gut; septum transversum; epicardium; epicardial-derived cells; valves; conduction system; compact myocardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Burch, JBE Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA Fox Chase Canc Ctr 7701 Burholme Ave Philadelphia PA USA 19111
Citazione:
C. MacNeill et al., "Modular regulation of cGATA-5 gene expression in the developing heart and gut", DEVELOP BIO, 217(1), 2000, pp. 62-76

Abstract

The evolutionarily conserved GATA-5 transcription factor is an early and persistent marker of heart and gut development in diverse vertebrate species. To search for control regions that might regulate the chicken GATA-5 (cGATA-5) gene, we assayed a set of cGATA-5/lacZ constructs in transgenic mice and found evidence for two functionally conserved control regions that regulate different facets of cGATA-5 gene expression. The more distal control region is activated in embryonic endoderm at the head-fold stage, whereas the other control region contains a regulatory module that is activated in a restricted region of endoderm following closure of the gut tube. Remarkably, the latter control region also contains a complex regulatory module that is activated in the cardiac crescent at the head-fold stage and subsequently functions in several mesodermal components of the developing heart, including the outer (epicardial) layer. We discuss these results in terms of possible contributions of epicardial-derived cells to the formation of heart valves, conduction tissue, and compact myocardium. These transgenes thus reveal, and provide a means to further analyze, transcriptional programs for several facets of heart morphogenesis and gut development. (C) 2000 AcademicPress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:32:06