Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IONIC MECHANISMS OF TETRANDRINE IN CULTURED RAT AORTIC SMOOTH-MUSCLE CELLS
Autore:
WU SN; HWANG TL; JAN CR; TSENG CJ;
Indirizzi:
TAICHUNG VET GEN HOSP,DEPT MED EDUC & RES,386 TA CHUNG 1ST RD KAOHSIUNG TAIWAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 327, anno: 1997,
pagine: 233 - 238
SICI:
0014-2999(1997)327:2-3<233:IMOTIC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL CURRENTS; MEDICINAL HERB ORIGIN; ACTIVATION; VEIN;
Keywords:
SMOOTH MUSCLE CELL, VASCULAR; TETRANDRINE; CA2+ CURRENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Wu et al., "IONIC MECHANISMS OF TETRANDRINE IN CULTURED RAT AORTIC SMOOTH-MUSCLE CELLS", European journal of pharmacology, 327(2-3), 1997, pp. 233-238

Abstract

Tile ionic mechanism of tetrandrine, an alkaloid extracted from the Chinese medicinal herb Radix stephania tetrandrae, was investigated in A7r5 vascular smooth muscle cells. The nystatin-perforated whole-cell voltage-clamp technique was performed to examine the effects of tetrandrine on ionic currents. Tetrandrine (1-100 mu M) reversibly caused aninhibition of L-type voltage-dependent Ca2+ current (I-Ca,I-L) in a concentration-dependent manner. Tetrandrine did not cause any change inthe overall shape of the current-voltage relationship of I-Ca,I-L. The IC50 value of tetrandrine-induced inhibition of I-Ca,I-L was 5 mu M. In the presence of Bay K 8644 (3 mu M) or cyclopiazonic acid (30 mu M), tetrandrine still produced a significant inhibition of I-Ca,I-L. The inhibitory effects of tetrandrine on I-Ca,I-L exhibited tonic and use-dependent characteristics. Moreover, tetrandrine (3 mu M) Shifted the steady-state inactivation curve of I-Ca,I-L to more negative membrane potentials by approximately -15 mV. These results indicate that tetrandrine directly inhibits the voltage-dependent L-type Ca2+ current invascular smooth muscle cells, which may predominantly contribute to the vasodilatory actions of tetrandrine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:47:21