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Titolo:
Effects of proton beam irradiation on uveal melanomas: a comparative studyof Ki-67 expression in irradiated versus non-irradiated melanomas
Autore:
Chiquet, C; Grange, JD; Ayzac, L; Chauvel, P; Patricot, LM; Devouassoux-Shisheboran, M;
Indirizzi:
Univ Lyons, Hop Croix Rousse, Dept Ophthalmol, F-69317 Lyon, France Univ Lyons Lyon France F-69317 se, Dept Ophthalmol, F-69317 Lyon, France Univ Lyons, Lyon Sud Hosp, Dept Biostat, F-69317 Lyon, France Univ Lyons Lyon France F-69317 Hosp, Dept Biostat, F-69317 Lyon, France Univ Lyons, Lyon Sud Hosp, Dept Pathol, F-69317 Lyon, France Univ Lyons Lyon France F-69317 d Hosp, Dept Pathol, F-69317 Lyon, France Biomed Cyclotron, Nice, France Biomed Cyclotron Nice FranceBiomed Cyclotron, Nice, France
Titolo Testata:
BRITISH JOURNAL OF OPHTHALMOLOGY
fascicolo: 1, volume: 84, anno: 2000,
pagine: 98 - 102
SICI:
0007-1161(200001)84:1<98:EOPBIO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL NUCLEAR ANTIGEN; MONOCLONAL-ANTIBODY KI-67; FLOW-CYTOMETRY; CHOROIDAL MELANOMA; PROGNOSTIC FACTORS; DNA-PLOIDY; PROLIFERATION; ENUCLEATION; INDEX; PC-10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Grange, JD Univ Lyons, Hop Croix Rousse, Dept Ophthalmol, 93 Grande Rue Croix Rousse,F-69317 Lyon, France Univ Lyons 93 Grande Rue Croix Rousse LyonFrance F-69317 ance
Citazione:
C. Chiquet et al., "Effects of proton beam irradiation on uveal melanomas: a comparative studyof Ki-67 expression in irradiated versus non-irradiated melanomas", BR J OPHTH, 84(1), 2000, pp. 98-102

Abstract

Aims-To assess the cellular proliferation using the monoclonal antibody Ki-67, in paraffin embedded uveal melanomas irradiated by proton beam, as well as in non-irradiated uveal melanomas. Methods-30 enucleated eyes were included for histopathogical study and Ki-67 immunostaining. Patients were enucleated between 1991 and 1995 for uvealmelanoma, 14 after proton beam irradiation and 16 without treatment (control group). The mean follow up period was 2.5 years after diagnosis and 1 year after enucleation. Results-A significant: relation was found between Ki-67 score and mitotic index (r = 0.56, p = 0.001), histological largest tumour diameter (r = 0.38, p = 0.03), fibrosis (r = -0.35, p = 0.05), absence of tumoral pigmentation (p = 0.05), and presence of vascular thrombosis (19 0.03). The Ki-67 score was significantly higher in the non-irradiated group (p = 0.01) and in the group of patients whose cause of enucleation was tumoral evolution (p = 0.005) compared with the group of patients enucleated after neovascular glaucoma. The Ki-67 score was very high in a case of orbital recurrence of uveal melanoma and metastatic death. 70% of metastasised tumours showed a Ki-67score higher than the median value. Conclusion-Ki-67 labelling is a reliable method of estimating the proliferative activity in uveal melanomas after proton beam irradiation. The Ki-67 score is significantly correlated with prognostic variables (mitotic index and histological largest tumour diameter), and with radiation effects afterproton beam irradiation.

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Documento generato il 03/12/20 alle ore 16:03:31