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Titolo:
Sponge delivery variables and tissue levels of 5-fluorouracil
Autore:
Wilkins, MR; Occleston, NL; Kotecha, A; Waters, L; Khaw, PT;
Indirizzi:
Inst Ophthalmol, Dept Pathol, Wound Healing Res Unit, London EC1V 9EL, England Inst Ophthalmol London England EC1V 9EL s Unit, London EC1V 9EL, England Moorfields Eye Hosp, Glaucoma Unit, London, England Moorfields Eye Hosp London England Hosp, Glaucoma Unit, London, England
Titolo Testata:
BRITISH JOURNAL OF OPHTHALMOLOGY
fascicolo: 1, volume: 84, anno: 2000,
pagine: 92 - 97
SICI:
0007-1161(200001)84:1<92:SDVATL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAUCOMA FILTRATION SURGERY; INTRAOCULAR-LENS IMPLANTATION; BLEB-RELATED ENDOPHTHALMITIS; MITOMYCIN-C TRABECULECTOMY; OPEN-ANGLE GLAUCOMA; ADJUNCTIVE MITOMYCIN; CATARACT-EXTRACTION; FILTERING SURGERY; TRIPLE PROCEDURE; FLUOROURACIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Khaw, PT Inst Ophthalmol, Dept Pathol, Wound Healing Res Unit, Bath St, London EC1V9EL, England Inst Ophthalmol Bath St London England EC1V 9EL EC1V9EL, England
Citazione:
M.R. Wilkins et al., "Sponge delivery variables and tissue levels of 5-fluorouracil", BR J OPHTH, 84(1), 2000, pp. 92-97

Abstract

Aim-To study how the delivery of 5-fluorouracil (5-FU) to ocular tissues is affected by altering delivery variables. Method-Sponge(s) soaked in radiolabelled 5-FU were placed between the conjunctiva and sclera of pig eyes. Application time, sponge size, sponge make (Altomed, Weck, Merocel), and 5-FU concentration were varied. Conjunctival and scleral tissue levels were determined in samples taken from the application site. Results-Dose-response curves for scleral and conjunctival 5-FU levels against application time showed increasing tissue levels that reached a plateauafter 2-3 minutes. Application beyond 3 minutes did not increase tissue levels. There was no difference in tissue levels between 7x4 and 3.5x2 mm sponges. Altomed sponges produced 5-FU tissue levels that were twice as high as those obtained with Weck-cell (p<0.01) or Merocel (p<0.02) sponges. Changing the 5-FU concentration from 25 mg/ml to 6.25 mg/ml reduced the conjunctival concentration by at factor of 3.5 (p<0.003). Conclusion-Application time up to 3 minutes, sponge make, and 5-FU concentration can have a large effect on the tissue delivery of 5-FU. Application time beyond 3 minutes, using 3.5x2 mmr or 7x4 mm sponges, and replacing sponges every minute did not have a significant effect on tissue levels. This study models the effect that different variables can have on the ocular tissue levels of an antimetabolite applied intraoperatively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 11:39:24