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Titolo:
Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women
Autore:
Daidone, MG; Luisi, A; Martelli, G; Benini, E; Veneroni, S; Tomasic, G; De Palo, G; Silvestrini, R;
Indirizzi:
Ist Nazl Studio & Cura Tumori, I-20133 Milan, Italy Ist Nazl Studio & CuraTumori Milan Italy I-20133 , I-20133 Milan, Italy
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 2, volume: 82, anno: 2000,
pagine: 270 - 277
SICI:
0007-0920(200001)82:2<270:BAOATT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 PROTEIN ACCUMULATION; THYMIDINE LABELING INDEX; BCL-2 PROTEIN; ADJUVANT CHEMOTHERAPY; COMBINATION CHEMOTHERAPY; PROGNOSTIC MARKERS; HORMONE RECEPTORS; POOR RESPONSE; EXPRESSION; THERAPY;
Keywords:
bcl-2 expression; cell proliferation; elderly patients; hormone responsiveness; p53 expression; oestrogen receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Daidone, MG Ist Nazl Studio & Cura Tumori, Via Venezian 1, I-20133 Milan, Italy Ist Nazl Studio & Cura Tumori Via Venezian 1 Milan Italy I-20133
Citazione:
M.G. Daidone et al., "Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women", BR J CANC, 82(2), 2000, pp. 270-277

Abstract

The predictive role of tumour proliferative rate and expression of p53, bcl-2 and bar proteins, alone and in association with tumour size, nodal involvement and oestrogen receptors (ER), was analysed on 145 elderly patients (greater than or equal to 70 years of age) with histologically assessed node-positive breast cancers treated with radical or conservative surgery plusradiotherapy followed by adjuvant tamoxifen fort least 1 year. The 7-year probability of relapse was significantly higher for patients with tumours rapidly proliferating (hazard ratio (HR) = 2.0, P = 0.01), overexpressing p53 (HR = 4.4, P = 0.0001), weakly or not exhibiting bcl-2(HR = 1.9, P = 0.02), without ERs (HR = 3.4, P = 0.0001) or with greater than or equal to 4 positive lymph nodes (HR = 2.3, P = 0.003) than for patients with tumours expressing the opposite patho-biological profile; Conversely, tumour size and bar expression failed to influence relapse-free survival. Adjustment for the duration of tamoxifen treatment did not change these findings. Oestrogen receptors; cell proliferation, p53 accumulation and bcl-2 expression were also predictive for overall survival. Within ER-positive tumours, cell proliferation, p53 accumulation, bcl-2 expression and lymph node involvement provided significant and independent information for relapse and, in association, identified subgroups of patients with relapse probabilities of 20% (low-risk group, exhibiting only one unfavourable factor) to 90% (high-risk group, exhibiting three unfavourable factors). Such data could represent the initial framework for a biologically tailored therapy even for elderly patients and highlight the importance of a patho-biological characterization of their breast cancers. (C) 2000 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:44:06