Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Propofol increases agonist efficacy at the GABA(A) receptor
Autore:
OShea, SM; Wong, LC; Harrison, NL;
Indirizzi:
Univ Chicago, Dept Pharmacol & Physiol Sci, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ol & Physiol Sci, Chicago, IL 60637 USA Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 esia & Crit Care, Chicago, IL 60637 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 852, anno: 2000,
pagine: 344 - 348
SICI:
0006-8993(20000110)852:2<344:PIAEAT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE BINDING; NEURONS; MIDAZOLAM; RAT; PHARMACOLOGY; ANESTHETICS; ACTIVATION; AFFINITY; DIAZEPAM; CHANNELS;
Keywords:
GABA(A) receptor; recombinant GABA(A)-R; HEK 293; whole-cell voltage clamp; anesthetic; allosteric modulator; apparent affinity; partial agonist; ligand-gated ion channel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Harrison, NL Cornell Univ, Weill Med Coll, Dept Anesthesiol, Lab Mol Neuropharmacol, 525 E 68th St, New York, NY 10021 USA Cornell Univ 525 E 68th StNew York NY USA 10021 NY 10021 USA
Citazione:
S.M. O'Shea et al., "Propofol increases agonist efficacy at the GABA(A) receptor", BRAIN RES, 852(2), 2000, pp. 344-348

Abstract

Using the whole-cell patch-clamp technique, we have determined that propofol, but not midazolam, increases the efficacy of piperidine-4-sulphonic acid (P4S), a partial agonist at alpha(1)beta(1)gamma(2s) GABA(A) receptors expressed in HEK 293 cells. These findings are consistent with the idea that propofol facilitates receptor gating, while midazolam increases receptor occupancy by the agonist. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:00:56