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Titolo:
The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat
Autore:
Cates, PS; OByrne, KT;
Indirizzi:
Univ London Kings Coll, GKT Sch Biomed Sci, Div Anat Cell & Human Biol, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL l, London SE1 1UL, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 853, anno: 2000,
pagine: 151 - 155
SICI:
0006-8993(20000117)853:1<151:TAPMIH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE SECRETION; HYPOGLYCEMIA-INDUCED INHIBITION; CORTICOTROPIN-RELEASING HORMONE; PULSE-GENERATOR ACTIVITY; PREOPTIC AREA; BRAIN-STEM; RHESUS-MONKEY; PARAVENTRICULAR NUCLEUS; ENDOGENOUS OPIOIDS; NEURONS;
Keywords:
area postrema; luteinising hormone; hypoglycaemia; GnRH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: O'Byrne, KT Univ London Kings Coll, GKT Sch Biomed Sci, Div Anat Cell & Human Biol, Guys Campus, London SE1 1UL, England Univ London Kings Coll Guys Campus London England SE1 1UL and
Citazione:
P.S. Cates e K.T. O'Byrne, "The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat", BRAIN RES, 853(1), 2000, pp. 151-155

Abstract

The caudal brainstem has been implicated in mediating the suppressive effect of glucoprivation on the reproductive neuroendocrine axis, specifically inhibition of pulsatile gonadotrophin-releasing hormone (GnRH)/luteinising hormone (LH) release in the rat. In the present study, removal of the area postrema completely prevented the profound inhibitory effect of insulin-induced hypoglycaemic stress on pulsatile LH release. These results suggest a pivotal role for this brainstem structure in mediating hypoglycaemic stress-induced suppression of the hypothalamic GnRH pulse generator. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:16:45