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Titolo:
Regulation of protein mobility in cell membranes: A dynamic corral model
Autore:
Leitner, DM; Brown, FLH; Wilson, KR;
Indirizzi:
Univ Calif San Diego, Dept Biochem & Chem, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 & Chem, La Jolla, CA 92093 USA
Titolo Testata:
BIOPHYSICAL JOURNAL
fascicolo: 1, volume: 78, anno: 2000,
parte:, 1
pagine: 125 - 135
SICI:
0006-3495(200001)78:1<125:ROPMIC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-PARTICLE TRACKING; FLUID MOSAIC MODEL; LATERAL DIFFUSION; BIOLOGICAL-MEMBRANES; ERYTHROCYTE-MEMBRANE; PLASMA-MEMBRANE; SKELETON; MOTION; BAND-3; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Leitner, DM Univ Calif San Diego, Dept Biochem & Chem, Box 0339, La Jolla,CA 92093 USA Univ Calif San Diego Box 0339 La Jolla CA USA 92093 92093 USA
Citazione:
D.M. Leitner et al., "Regulation of protein mobility in cell membranes: A dynamic corral model", BIOPHYS J, 78(1), 2000, pp. 125-135

Abstract

We analyze a two-state stochastic corral model for regulation of protein diffusion in a cell membrane. This model could mimic control of protein transport in the membrane by the cytoskeleton. The dynamic corral acts as a gate which when open permits an otherwise trapped protein to escape to a neighboring corral in the cytoskeletal network. We solve for the escape rate over a wide range of parameters of the model, and compare these results with Monte Carte simulations. Upon introducing measured values of the model parameters for Band 3 in erythrocyte membranes, we are able to estimate the value for one unknown parameter, the average rate at which the corral closes. The ratio of calculated closing rate to measured opening rate is roughly 100:1, consistent with a gating mechanism whereby protein mobility is regulated by dissociation and reassociation of segments of the cytoskeletal network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:53:17