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Titolo:
Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid
Autore:
Valenti, P; Bisi, A; Rampa, A; Belluti, F; Gobbi, S; Zampiron, A; Carrara, M;
Indirizzi:
Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 harmaceut Sci, I-40126 Bologna, Italy Univ Padua, Dept Pharmacol, I-35131 Padua, Italy Univ Padua Padua Italy I-35131 dua, Dept Pharmacol, I-35131 Padua, Italy
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 1, volume: 8, anno: 2000,
pagine: 239 - 246
SICI:
0968-0896(200001)8:1<239:SABAOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; POTENTIAL ANTITUMOR AGENTS; OVARIAN-CARCINOMA CELLS; TUMOR-NECROSIS-FACTOR; 9-OXO-9H-XANTHENE-4-ACETIC ACID; XANTHENONE-4-ACETIC ACID; BLOOD-FLOW; NSC-347512; INVIVO; MICE;
Keywords:
flavone-8-acetic acid; antitumour compounds; human colon adenocarcinoma; ovarian adenocarcinoma; macrophages; lytic properties;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Valenti, P Univ Bologna, Dept Pharmaceut Sci, Via Belmeloro 6, I-40126 Bologna, Italy Univ Bologna Via Belmeloro 6 Bologna Italy I-40126 ogna, Italy
Citazione:
P. Valenti et al., "Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid", BIO MED CH, 8(1), 2000, pp. 239-246

Abstract

Some rigid analogues of flavone-8-acetic acid are described. Direct in vitro toxicity of the synthesised compounds was evaluated towards four tumoralcell lines and the ability of these compounds to stimulate mouse peritoneal macrophages in culture to become tumoricidal (indirect toxicity) was alsostudied. All compounds were able to induce direct cytotoxicity only at very high concentrations but showed a remarkable indirect activity. In particular compound 4d was able to significantly increase macrophage lyric properties and has been selected for further investigations. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:02:06