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Titolo:
EFFECT OF MILNACIPRAN AND DESIPRAMINE ON NORADRENERGIC ALPHA(2)-AUTORECEPTOR SENSITIVITY
Autore:
MORET C; BRILEY M;
Indirizzi:
CTR RECH PIERRE FABRE,DIV NEUROBIOL 1,17 AVE JEAN MOULIN F-81100 CASTRES FRANCE
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 6, volume: 18, anno: 1994,
pagine: 1063 - 1072
SICI:
0278-5846(1994)18:6<1063:EOMADO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HYPOTHALAMUS; UPTAKE INHIBITORS; EVOKED RELEASE; RABBIT CAUDATE; ANTIDEPRESSANT; BRAIN; AUTORECEPTORS; ADRENOCEPTORS; HYDROCHLORIDE; STIMULATION;
Keywords:
ANTIDEPRESSANTS; CHRONIC TREATMENTS; DESIPRAMINE; GUANABENZ; HYPOTHALAMUS; MILNACIPRAN; NORADRENALINE RELEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C. Moret e M. Briley, "EFFECT OF MILNACIPRAN AND DESIPRAMINE ON NORADRENERGIC ALPHA(2)-AUTORECEPTOR SENSITIVITY", Progress in neuro-psychopharmacology & biological psychiatry, 18(6), 1994, pp. 1063-1072

Abstract

1. The effects of chronic administration with milnacipran and desipramine on the noradrenergic alpha(2)-autoreceptor sensitivity in the rathypothalamus were compared. 2. Rats were administered, in their diet,milnacipran (50 mg/kg/day for 21 days, 24 h wash-out), desipramine (35 mg/kg/day for 21 days, 24 h wash out) or desipramine (14 mg/kg/day for 21 days, 41 h wash-out). Hypothalamic slices were incubated with [H-3]noradrenaline, superfused and stimulated electrically. 3. Chronic administration with milnacipran did not modify basal or electrically induced release of [H-3]noradrenaline, tissue incorporation of [H-3]noradrenaline or the sensitivity of the alpha(2)-autoreceptor assessed by the inhibition of the stimulation-evoked release of [H-3]noradrenalineby the alpha(2)-adrenoceptor agonist, guanabenz, in comparison to controls. After chronic desipramine (35 mg/kg), basal and evoked release of [H-3]noradrenaline were increased, tissue incorporation of [H-3]noradrenaline decreased and the inhibitory effect of guanabenz was diminished. At the lower dose (14 mg/kg), chronic desipramine increased onlythe evoked release of noradrenaline but did not modify the sensitivity of the alpha(2)-autoreceptor. 4. Desipramine at 35 mg/kg remains in the tissue after 24 h wash out, causing a reduction of uptake and complicating the interpretation of the data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:42:03