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Titolo:
An in vitro investigation of the PEMA/THFMA polymer system as a biomaterial for cartilage repair
Autore:
Wyre, RM; Downes, S;
Indirizzi:
Queens Med Ctr, Sch Biomed Sci, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH i, Nottingham NG7 2UH, England
Titolo Testata:
BIOMATERIALS
fascicolo: 4, volume: 21, anno: 2000,
pagine: 335 - 343
SICI:
0142-9612(200002)21:4<335:AIVIOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN CHONDROCYTES INVITRO; BOVINE ARTICULAR CHONDROCYTES; HETEROCYCLIC METHACRYLATES; CLINICAL-APPLICATIONS; SUB-POPULATIONS; IN-VITRO; CULTURE; COLLAGEN; MATRIX; PHENOTYPE;
Keywords:
chondrocytes; cartilage repair; polymer; biomaterials; methacrylate; cell culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Wyre, RM Royal S Hants Hosp, Steve Mills Transplant Lab, Brintons Terrace,Off St Marys Rd, Southampton SO1 OYG, Hants, England Royal S Hants Hosp Brintons Terrace,Off St Marys Rd Southampton Hants England SO1 OYG
Citazione:
R.M. Wyre e S. Downes, "An in vitro investigation of the PEMA/THFMA polymer system as a biomaterial for cartilage repair", BIOMATERIAL, 21(4), 2000, pp. 335-343

Abstract

A polymer system consisting of poly(ethyl methacrylate)/tetrahydrofurfurylmethacrylate (PEMA/THFMA) was investigated as a biomaterial for cartilage repair using chondrocyte culture. The PEMA/THFMA system and Thermanox control were shown to support chondrocytes seeded directly onto the surface for up to 28 days in culture. Differences were seen between the PEMA/TKFMA system and Thermanox in DNA content, proliferation and glycosaminoglycon (GAG) synthesis. There was a significantly greater medium : cell GAG ratio for the PEMA/THFMA system compared to Thermanox. A greater number of chondrocytesisolated from the superficial zone of bovine cartilage attached to the PEMA/THFMA system compared to cells isolated from the deep zone, whereas the converse was seen for Thermanox. Matrix constituents including collagen typeII were synthesised indicating that the differentiated phenotype was maintained for some of the chondrocytes, although the production of type I collagen indicated that dedifferentiation of some of the chondrocytes had occurred. In conclusion, this study has shown that the PEMA/THFMA system can support chondrocytes in vitro and together with further investigations could lead to the development of the polymer as an ideal candidate for articular cartilage repair. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:36:02