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Titolo:
Influence of stimulus control on the excitability of the electrically elicited blink reflex in patients with schizophrenia
Autore:
Meincke, U; Topper, R; Hoff, P;
Indirizzi:
Aachen Tech Univ, Dept Psychiat & Psychotherapy, D-52074 Aachen, Germany Aachen Tech Univ Aachen Germany D-52074 therapy, D-52074 Aachen, Germany Aachen Tech Univ, Dept Neurol, D-52074 Aachen, Germany Aachen Tech Univ Aachen Germany D-52074 Neurol, D-52074 Aachen, Germany
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 43 - 50
SICI:
0006-3223(20000101)47:1<43:IOSCOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STARTLE REFLEX; R3 COMPONENT; STIMULATION; HABITUATION; MODULATION; INHIBITION; RESPONSES; DEFICITS; DISORDER; LESIONS;
Keywords:
attentional dysfunctions; blink reflex; excitability; schizophrenia; self-elicitation; startle response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Meincke, U Aachen Tech Univ, Dept Psychiat & Psychotherapy, Pauwelsstr 30,D-52074 Aachen, Germany Aachen Tech Univ Pauwelsstr 30 Aachen Germany D-52074 Germany
Citazione:
U. Meincke et al., "Influence of stimulus control on the excitability of the electrically elicited blink reflex in patients with schizophrenia", BIOL PSYCHI, 47(1), 2000, pp. 43-50

Abstract

Background: In humans, the excitability of the electrically evoked blink reflex is influenced by the subject's attention to the stimulus. The early reflex component RI has been found to be facilitated in conditions of increased selective attention, whereas the late components R2 and R3 exhibited a marked suppression. Distraction from the stimulus lends to enhanced R2 and R3 magnitudes. Methods: We investigated the excitability of the distinct reflex components in 19 patients with schizophrenia and 19 healthy control subjects. In thecontrol condition (EE), stimulation was elicited by the experimenter; in asecond condition (SE), subjects released a key to evoke the reflex themselves,Results: The SE patients with schizophrenia exhibited an abnormally increased RI facilitation and an impaired R2 inhibition in comparison with normalcontrol subjects. An R3 component could be registered in EE in 13 of 19 patients brit only in one control subject; SE resulted in a complete suppression of this component in all but Two patients with schizophrenia. Conclusions: The abnormal RI facilitation and the impaired R2 inhibition may be regarded as neurophysiological markers of defective information processing in a condition of increased selective attention to a self-controlled stimulus in patients with schizophrenia, The enhanced excitability of the R3 component under standard conditions indicates defective attentional mechanisms in patients with schizophrenia in an uninstructed passive condition attending a stimulus triggered by the experimenter.

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Documento generato il 29/10/20 alle ore 23:03:26