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Titolo:
Essential fatty acids, lipid membrane abnormalities, and the diagnosis andtreatment of schizophrenia
Autore:
Fenton, WS; Hibbeln, J; Knable, M;
Indirizzi:
Stanley Treatment Programs, Rockville, MD USA Stanley Treatment Programs Rockville MD USA Programs, Rockville, MD USA NIAAA, Rockville, MD 20852 USA NIAAA Rockville MD USA 20852NIAAA, Rockville, MD 20852 USA Stanley Fdn Res Program, Bethesda, MD USA Stanley Fdn Res Program Bethesda MD USA dn Res Program, Bethesda, MD USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 8 - 21
SICI:
0006-3223(20000101)47:1<8:EFALMA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; NIACIN CHALLENGE TEST; DOCOSAHEXAENOIC ACID; PHOSPHOLIPASE A(2); ERYTHROCYTE-MEMBRANES; SIGNAL-TRANSDUCTION; TARDIVE-DYSKINESIA; SKIN FIBROBLASTS; ARACHIDONIC-ACID; SEROTONINERGIC NEUROTRANSMISSION;
Keywords:
schizophrenia; membrane physiology; essential fatty acids; psychopharmacology; treatment; phospholipids;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Fenton, WS 500 W Montgomery Ave, Rockville, MD 20850 USA 500 W MontgomeryAve Rockville MD USA 20850 ille, MD 20850 USA
Citazione:
W.S. Fenton et al., "Essential fatty acids, lipid membrane abnormalities, and the diagnosis andtreatment of schizophrenia", BIOL PSYCHI, 47(1), 2000, pp. 8-21

Abstract

Recent research suggests that deficient uptake or excessive breakdown of membrane phospholipids may be associated with schizophrenia. We review available clinical research on abnormalities inn membrane fatty acid compositionand metabolism in schizophrenia, and therapeutic trials of fatty acid in this disorder. All potentially, relevant English-language articles were identified from the medical and psychiatric literature with the aid of computer searches rising key words such as lipids, phospholipids, prostaglandins and schizophrenia. All studies which include human subjects are reviewed. Empirical studies related to membrane hypotheses of schizophrenia focus on: 1) assessment of prostaglandins (PGI and their essential fatty acid (EFA)precursors in the tissues of patients with schizophrenia; 2) evaluation ofthe niacin flush test as a possible diagnostic marker; 3) evaluation of phospholipase enzyme activity; 4) NMR spectroscopy studies of brain phospholipid metabolism, and 5) therapeutic trials of PG precursors for the treatment of schizophrenia. The most consistent clinical findings include red bloodcell fatty acid membrane abnormalities, NMR spectroscopy evidence of increased phospholipid turnover and a therapeutic effect of omega-3 fatty acid supplementation of neuroleptic treatment in some schizophrenia patients,Studies of EFA metabolism have proved fruitful for generating and testing novel etiologic hypotheses and new therapeutic agents for schizophrenia. Greater attention to factors that influence tissue EFA levels such as diet, tobacco and alcohol al-e required to reconcile inconsistent findings. Treatment studies, although promising, require independent replication. (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:50:02