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Titolo:
Magnetic resonance lymphography of profundus lymph nodes with liposomal gadolinium-diethylenetriamine pentaacetic acid
Autore:
Fujimoto, Y; Okuhata, Y; Tyngi, S; Namba, Y; Oku, N;
Indirizzi:
Univ Shizouka, Sch Pharmaceut Sci, Dept Radiobiochem, Shizuoka 4228526, Japan Univ Shizouka Shizuoka Japan 4228526 diobiochem, Shizuoka 4228526, Japan Nihon Univ, Sch Med, Itabashi Ku, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 ch Med, Itabashi Ku, Tokyo 1738610, Japan Nippon Fine Chem Co Ltd, Takasago, Hyogo 6760074, Japan Nippon Fine Chem Co Ltd Takasago Hyogo Japan 6760074 Hyogo 6760074, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 1, volume: 23, anno: 2000,
pagine: 97 - 100
SICI:
0918-6158(200001)23:1<97:MRLOPL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MRI CONTRAST AGENT; LIPID-COMPOSITION; CIRCULATION TIME; GD-DTPA; ENHANCEMENT; SIZE; BIODISTRIBUTION; RELAXIVITY; INVIVO;
Keywords:
magnetic resonance imaging; liposome; lymphography; contrast enhancement; gadolinium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Oku, N Univ Shizouka, Sch Pharmaceut Sci, Dept Radiobiochem, Shizuoka 4228526, Japan Univ Shizouka Shizuoka Japan 4228526 hem, Shizuoka 4228526, Japan
Citazione:
Y. Fujimoto et al., "Magnetic resonance lymphography of profundus lymph nodes with liposomal gadolinium-diethylenetriamine pentaacetic acid", BIOL PHAR B, 23(1), 2000, pp. 97-100

Abstract

Lymphography, especially imaging of profundus lymph nodes, is a useful tool for diagnosis of cancer metastases in lymph nodes. However, positive enhancement agents for magnetic resonance lymphography (MRL) have not been available, since the positive imaging agents so far introduced are low-molecular-weight materials that are not trapped in lymph nodes. For the purpose of improved positive enhanced MRL, we employed liposomes as carriers of a positive enhancer, gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Magnetic resonance (MR) imaging was performed after subcutaneous injection ofGd-liposomes into the hind feet of rabbits which had reactive enlarged retroperitoneal lymph nodes. As a result, not only popliteal but also profundus retroperitoneal lymph nodes were positively enhanced by Gd-liposomes, especially after 20 min massage of the injected sites. Gd-Liposomes containingdipalmitoylphosphatidylglycerol were more effective than Gd-liposomes containing palmityl-D-glucuronide, a type of long-circulating liposomes, suggesting that liposomal accumulation in lymph node is, at least partly, mediated by the trapping of liposomes by macrophages, These data show that liposomes modified with cd-DTPA are effective for positive enhancement of both regional and profundus lymph nodes in MR lymphography.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:16:49