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Titolo:
High density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences
Autore:
Francis, GA;
Indirizzi:
Univ Alberta, Lipid & Lipoprot Res Grp, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 Grp, Edmonton, AB T6G 2S2, Canada Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 Med, Edmonton, AB T6G 2S2, Canada
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 2, volume: 1483, anno: 2000,
pagine: 217 - 235
SICI:
1388-1981(20000117)1483:2<217:HDLOIV>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; HERITABLE HYPERLIPIDEMIC RABBITS; HUMAN ATHEROSCLEROTIC LESIONS; BILIARY STEROL SECRETION; VASCULAR SMOOTH-MUSCLE; MACROPHAGE FOAM CELLS; HUMAN-BLOOD-PLASMA; DOSE VITAMIN-E; LIPID-PEROXIDATION;
Keywords:
high density lipoprotein; oxidation; cholesterol; cholesterol efflux; atherosclerosis; cardioprotection; Tangier disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
142
Recensione:
Indirizzi per estratti:
Indirizzo: Francis, GA Univ Alberta, Lipid & Lipoprot Res Grp, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 n, AB T6G 2S2, Canada
Citazione:
G.A. Francis, "High density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences", BBA-MOL C B, 1483(2), 2000, pp. 217-235

Abstract

Elevated levels of plasma high density lipoprotein (HDL) are strongly predictive of protection against atherosclerotic vascular disease. HDL particles likely have several beneficial actions in vivo, including the initiation of reverse cholesterol transport. The apparent importance of oxidative modification of low density lipoprotein in atherogenesis raises the question ofhow oxidative modification of HDL might affect its cardioprotective actions. HDL is readily oxidized using numerous models of lipoprotein oxidation. In vitro evidence suggests oxidation might impair some protective actions, but actually enhance other mechanisms induced by HDL that prevent the accumulation of cholesterol in the artery wall. This article reviews the currentliterature concerning the relative oxidizability of HDL, the structural changes induced in HDL by oxidation in vitro, and the potential consequences of oxidative modification on the protective actions of HDL in vivo. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:22:49