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Titolo:
Synthesis of [F-18]fluoromethyl iodide, a synthetic precursor for fluoromethylation of radiopharmaceuticals
Autore:
Zheng, L; Berridge, MS;
Indirizzi:
Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 eland, Cleveland, OH 44106 USA
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 1, volume: 52, anno: 2000,
pagine: 55 - 61
SICI:
0969-8043(200001)52:1<55:SO[IAS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR;
Keywords:
fluorine-18; fluoromethyl iodide; precursor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Berridge, MS Case Western Reserve Univ, Dept Radiol, 11100 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 11100 Euclid Ave Cleveland OH USA 44106
Citazione:
L. Zheng e M.S. Berridge, "Synthesis of [F-18]fluoromethyl iodide, a synthetic precursor for fluoromethylation of radiopharmaceuticals", APPL RAD IS, 52(1), 2000, pp. 55-61

Abstract

[F-18]fluoroiodomethane was labeled via nucleophilic substitution of diiodomethane with [F-18]fluoride, and labeling conditions were optimized. The optimized labeling yield was 40 +/- 8% (decay-corrected). The synthesis and purification of [F-18]fluoroiodomethane took 15 min. The reactions of [F-18]fluoroiodomethane with amine, carboxylic acid, thiol and phenoxide groups produced fluoromethylated derivatives with various yields (12-95%). The results indicated that [F-18]fluoroiodomethane is a valuable synthetic precursor for the introduction of an [F-18]fluoromethyl group into radiopharmaceuticals. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:24:45