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Titolo:
Analysis of 4-ABP-DNA adducts and p53 alterations in urinary bladder carcinoma
Autore:
Romano, G; Garagnani, L; Boninsegna, A; Ferrari, P; Flamini, G; De Gaetani, C; Sgambato, A; Giovanni, F; Curigliano, G; Ferretti, G; Cittadini, A; Trentini, G;
Indirizzi:
Catholic Univ Sacred Heart, Sch Med, Giovanni XXIII Res Canc Ctr, Inst GenPathol, I-00168 Rome, Italy Catholic Univ Sacred Heart Rome Italy I-00168athol, I-00168 Rome, Italy Univ Modena, Dept Morphol Sci & Legal Med, Sect Anat Pathol, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Sect Anat Pathol, I-41100 Modena, Italy AUSL, Div Urol, Modena, Italy AUSL Modena ItalyAUSL, Div Urol, Modena, Italy
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5C, volume: 19, anno: 1999,
pagine: 4571 - 4576
SICI:
0250-7005(199909/10)19:5C<4571:AO4AAP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; 4-AMINOBIPHENYL-DNA ADDUCTS; AROMATIC-AMINES; CANCER; MUTATIONS; DNA; PATHWAYS; TOBACCO; SMOKERS; MICE;
Keywords:
4-ABP-DNA adducts; p53 overexpression/mutations; cigarette smoke; bladder cancer; molecular epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Romano, G Catholic Univ Sacred Heart, Sch Med, Giovanni XXIII Res Canc Ctr, Inst GenPathol, Lgo F Vito 1, I-00168 Rome, Italy Catholic Univ Sacred Heart Lgo F Vito 1 Rome Italy I-00168 taly
Citazione:
G. Romano et al., "Analysis of 4-ABP-DNA adducts and p53 alterations in urinary bladder carcinoma", ANTICANC R, 19(5C), 1999, pp. 4571-4576

Abstract

Background: Activated intermediates of 4-aminobiphenyl (4-ABP) are able tocovalently interact with DNA to form adducts. There ir a large body of evidence indicating that carcinogen-DNA adduct formation can be one of the cancer initiating mechanisms. Materials and Methods. (4-ABP)-induced DNA damage in association with p53 overexpression and mutations were evaluated in specimens of urothelial bladder cancers from 106 patients. Results: 4-ABP-DNAadduct levels resulted higher in smokers compared to non smokers, with a borderline statistical value. p53 nuclear overexpression was related to tumor grading, while no significant correlation with stage, 4-ABP-DNA adducts, smoking habit, and disease recurrence could be observed. Concerning molecular analysis, p53 point mutations were found in 17 of 106 cases (16%) and mutational pattern was significantly associated both with higher grade and stage, but no correlation was found with disease recurrence. Conclusions: These results suggest that other sources, in addition to tobacco smoke, may contribute to 4-ABP-DNA adducts formation in bladder tissue and that p53 expression/mutation cannot be considered a prognostic factor in bladder cancer.

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Documento generato il 05/12/20 alle ore 19:59:37