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Titolo:
Clinicopathological significance of the expression of CD44v2 in colorectalcancer
Autore:
Haruyama, K; Matsumura, Y; Moriya, Y; Kakizoe, T; Ochiai, A; Kawaguchi, M; Saito, T;
Indirizzi:
Natl Canc Ctr Hosp, Dept Med, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Hosp Tokyo Japan 1040045 ed, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Hosp, Dept Surg, Tokyo 1040045, Japan Natl Canc Ctr Hosp Tokyo Japan 1040045 , Dept Surg, Tokyo 1040045, Japan Natl Canc Ctr, Res Inst, Div Pathol, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104 tr, Res Inst, Div Pathol, Tokyo 104, Japan Tokyo Med Univ, Dept Med 4, Tokyo, Japan Tokyo Med Univ Tokyo JapanTokyo Med Univ, Dept Med 4, Tokyo, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5C, volume: 19, anno: 1999,
pagine: 4421 - 4428
SICI:
0250-7005(199909/10)19:5C<4421:CSOTEO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH ENDOTHELIUM; BREAST-CANCER; LYMPH-NODE; VARIANT; GENE; PROGNOSIS; RECEPTOR; PROTEINS; SURVIVAL; CELLS;
Keywords:
CD44; colorectal cancer; cancer prognosis; metastasis; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumura, Y Natl Canc Ctr Hosp, Dept Med, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan Natl Canc Ctr Hosp 5-1-1 Tsukiji Tokyo Japan 1040045 , Japan
Citazione:
K. Haruyama et al., "Clinicopathological significance of the expression of CD44v2 in colorectalcancer", ANTICANC R, 19(5C), 1999, pp. 4421-4428

Abstract

Expression of CD44 valiant isoforms has been reported to be correlated with faster progression of neoplastic diseases metastasis ann reduced survivalperiod In this study! the correlation between the expression of CD44v2 (v2) or CD44v6 (v6) and clinicopathological features was examined in Dukes B and C colorectal cancer using immunohistochemistry. V6 expression was not correlated with any clinicopathological indices or-prognosis in either Dukes B or C. On the other hand, v2 expression was correlated significantly with recurrence rate and poorer prognosis in Dukes B colorectal cancer although there was no correlation between v2 expression and prognosis in Dukes C patients. The results suggest that v2 is a candidate for a prognostic marker in Dukes B colorectal cancer. CD44v2 expression may be an indication for adopting adjuvant chemotherapy in patients without lymph node metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:18:42