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Titolo:
Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer
Autore:
Moser, PL; Kieback, DG; Hefler, L; Tempfer, C; Neunteufel, W; Gitsch, G;
Indirizzi:
Univ Freiburg, Med Ctr, Dept Obstet & Gynecol, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 ynecol, D-79106 Freiburg, Germany Innsbruck Univ, Dept Pathol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 athol, A-6020 Innsbruck, Austria Univ Vienna, Dept Obstet & Gynecol, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 stet & Gynecol, A-1010 Vienna, Austria Hosp Dornbirn, Dept Obstet & Gynecol, Dornbirn, Austria Hosp Dornbirn Dornbirn Austria Dept Obstet & Gynecol, Dornbirn, Austria
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5C, volume: 19, anno: 1999,
pagine: 4391 - 4393
SICI:
0250-7005(199909/10)19:5C<4391:IDOMM(>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC FACTORS; EXPRESSION;
Keywords:
metalloproteinases; cervical cancer; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Gitsch, G Univ Freiburg, Med Ctr, Dept Obstet & Gynecol, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 ermany
Citazione:
P.L. Moser et al., "Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer", ANTICANC R, 19(5C), 1999, pp. 4391-4393

Abstract

Objective: Matrix metalloproteinases (MMPs) al-e a family of zinc-dependent metalloendopeptidases which participate in the degradation of collagen and other extracellular matrix macromolecules. Expression of gelatonic MMPs, such as MMP-2 has been linked to enhanced tumor invasion and metastases in in vitro and in vivo model systems. If was the aim of this study to determine whether the expression of MMP-1, MMP-2, and TIMP-2 correlates with survival in patients with surgically treated cervical cancer stage IB. Methods: A sample of 154 paraffin-embedded tumor specimens of surgical treated FIGO stage IB cervical cancer was immunohistochemically investigated Results: MMP-1, MMP-2, and TIMP-2 were detected by immunohistochemistry in 74 % (113/154), 32 % (49/154), and 80 % (107/154) of the tumor samples, respectively. Correlation coefficients for MMP-1/MMP-2 MMP-1/TIMP-2 MMP-2/TIMP-2 were 0.14 (p = 0.12), 0.37 (p = 0.0001), and 0.17 (p:0.005), respectively. A significant correlation was found between MMP-1 and lymph node status (P < 0.01) and lymphvascular space invasion (P < 0.05). The expression of MMP-1 (log-rank test, p = 0.6), MMP-2 (log-rank test, p = 0.8), and TIMP-2 (log-rank test, p = 0.15) were not correlated with overall survival. Conclusion: MMP-1,detected by immunohistochemistry; seems to play a role in the development of lymphvascular space invasion and lymph node metastases, but is not helpful in predicting the prognosis of cervical cancer patients.

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Documento generato il 12/07/20 alle ore 06:25:20