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Titolo:
Ligand-receptor interactions studied by PET: implications for drug development
Autore:
Hietala, J;
Indirizzi:
Turku Univ, Cent Hosp, Turku PET Ctr, Turku, Finland Turku Univ Turku Finland Univ, Cent Hosp, Turku PET Ctr, Turku, Finland Turku Univ, Cent Hosp, Dept Psychiat, Turku, Finland Turku Univ Turku Finland Univ, Cent Hosp, Dept Psychiat, Turku, Finland
Titolo Testata:
ANNALS OF MEDICINE
fascicolo: 6, volume: 31, anno: 1999,
pagine: 438 - 443
SICI:
0785-3890(199912)31:6<438:LISBPI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE BINDING; NAIVE SCHIZOPHRENIC-PATIENTS; D2 DOPAMINE-RECEPTORS; ENDOGENOUS DOPAMINE; CONTINUOUS-INFUSION; STRIATAL D-2; HUMAN-BRAIN; EQUILIBRIUM; INHIBITION;
Keywords:
drug development; positron emission tomography; phase I; receptor; receptor occupancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hietala, J Turku PET Ctr, POB 52, FIN-20521 Turku, Finland Turku PET Ctr POB 52 Turku Finland FIN-20521 21 Turku, Finland
Citazione:
J. Hietala, "Ligand-receptor interactions studied by PET: implications for drug development", ANN MED, 31(6), 1999, pp. 438-443

Abstract

Positron emission tomography (PET) is a quantitative imaging method that can be used to characterize binding properties of specific target molecules such as various receptors, transporter molecules and enzymes irt vivo. Although already applied successfully, one Of the greatest challenges for the technique is to understand better the in vivo complexities of ligand-receptor (target) interaction. The PET technique can be used efficiently in animalstudies but, moss importantly, also in human studies. PET imaging of patients and healthy volunteers can generate information on human pathophysiology at a molecular level currently unobtainable with other methods. Modern imaging techniques are increasingly applied to drug discovery and development. There are many ways of utilizing PET in pharmacodynamic studies, one interesting approach being the indirect exploration of synaptic neurotransmission with receptor ligands. The receptor occupancy-type studies with PET are rapidly becoming a state-of-the-art method for verifying the mechanism of action of a given drug in man and especially for facilitating the dose-finding procedures in early drug development. Thus far, PET has been mainly applied to pharmacodynamic studies in the central nervous system. but will be used also in other areas of drug development such as cardiovascular diseasesand oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 21:05:28