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Titolo:
INHALATORY PENTAMIDINE THERAPY AND THE DURATION OF THE QT INTERVAL INHIV-INFECTED PATIENTS
Autore:
CARDOSO JS; MOTAMIRANDA A; CONDE C; MOURA B; ROCHAGONCALVES F; LECOUR H;
Indirizzi:
AVE DA BOAVISTA 2066,HABITACAO 14 P-4100 OPORTO PORTUGAL HOSP DE S JOAO,PORTO MED SCH,SERV CARDIOL P-4200 OPORTO PORTUGAL HOSP DE S JOAO,PORTO MED SCH,INFECT DIS SERV P-4200 OPORTO PORTUGAL
Titolo Testata:
International journal of cardiology
fascicolo: 3, volume: 59, anno: 1997,
pagine: 285 - 289
SICI:
0167-5273(1997)59:3<285:IPTATD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; PNEUMOCYSTIS-CARINII PNEUMONIA; INTRAVENOUS PENTAMIDINE; VENTRICULAR-TACHYCARDIA; ISETHIONATE;
Keywords:
INHALATORY PENTAMIDINE; QT INTERVAL PROLONGATION; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Cardoso et al., "INHALATORY PENTAMIDINE THERAPY AND THE DURATION OF THE QT INTERVAL INHIV-INFECTED PATIENTS", International journal of cardiology, 59(3), 1997, pp. 285-289

Abstract

We evaluated the effect of chronic Pneumocystis carinii pneumonia (PCP) prophylaxis, with a once a month dose of 300 mg of inhalatory pentamidine isethionate, on QT interval duration. We included 22 human immunodeficiency virus (HIV)-infected patients: 11 were on this medicationand 11 were not. The mio groups were matched for age, sex and HIV infection stage. No patient had any clinical condition or was under any medication known to affect the duration of the QT interval. The heart rate-corrected QT (QTc) was obtained by averaging the observations of three independent observers, QTc duration was similar in both groups. The time separating pentamidine administration and the performance of the ECG did not influence the results, neither did the duration of inhalatory pentamidine therapy. Our results suggest that inhalatory pentamidine does not prolong the QT interval duration and so, as opposed to what has been reported concerning intravenous pentamidine therapy, does not seem to induce an increased risk of torsades de pointes. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:11:19