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Titolo:
Altered glutamate metabolism is associated with reduced muscle glutathionelevels in patients with emphysema
Autore:
Engelen, MPKJ; Schols, AMWJ; Does, JD; Deutz, NEP; Wouters, EFM;
Indirizzi:
Maastricht Univ, Dept Pulm, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands pt Pulm, Maastricht, Netherlands Maastricht Univ, Dept Surg, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands pt Surg, Maastricht, Netherlands Asthma Ctr Hornerheide, Horn, Netherlands Asthma Ctr Hornerheide Horn Netherlands Hornerheide, Horn, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 161, anno: 2000,
pagine: 98 - 103
SICI:
1073-449X(200001)161:1<98:AGMIAW>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; SKELETAL-MUSCLE; AMINO-ACID; CANCER; PLASMA; CACHEXIA; EXERCISE; HEART; MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Engelen, MPKJ Univ Hosp Maastricht, Dept Pulmonol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht NetherlandsNL-6202 AZ
Citazione:
M.P.K.J. Engelen et al., "Altered glutamate metabolism is associated with reduced muscle glutathionelevels in patients with emphysema", AM J R CRIT, 161(1), 2000, pp. 98-103

Abstract

Chronic obstructive pulmonary disease (COPD) is often characterized by an impaired skeletal muscle energy metabolism, which is at least partly related to chronic hypoxia and a reduced diffusing capacity. We have found that muscle glutamate (Glu), which is negatively influenced by these conditions, was reduced in patients with severe COPD. The aim of this study was to investigate whether the reduced intracellular Glu level in patients with emphysema is associated with an increased muscle glycolytic metabolism Since Glu is an important substrate in the synthesis of glutamine (Gln) and glutathione (GSH), the influence of Glu status on muscle GSH and Gln was also examined. In 13 patients with emphysema and 25 control patients, arterial blood and biopsies from the vastus lateralis muscle were obtained. Expressed as a percentage of the control values, the patients with emphysema had reduced values for muscle Glu (64 +/- 12%; p < 0.001), GSH (76 +/- 23%; p < 0.01), and Gln (93 +/- 5%; p < 0.01), and higher values for lactate (p < 0.01) and pyruvate (p < 0.05). No differences were found in plasma values. Muscle Gluwas highly associated with GSH (R-2 = 0.61; P < 0.001), but not with Gln. This study illustrates that reduced Glu levels in skeletal muscle of patients with emphysema are possibly related to an enhanced glycolytic activity and associated with decreased GSH levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:49:58