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Titolo:
Airway-parenchyma uncoupling in nocturnal asthma
Autore:
Irvin, CG; Pak, J; Martin, RJ;
Indirizzi:
Univ Vermont, Colchester Res Facil, Colchester, VT 05446 USA Univ VermontColchester VT USA 05446 Res Facil, Colchester, VT 05446 USA Natl Jewish Med & Res Ctr, Div Pulm, Dept Med, Denver, CO USA Natl Jewish Med & Res Ctr Denver CO USA v Pulm, Dept Med, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Denver, CO 80202 USA Univ Colorado Denver COUSA 80202 ado, Hlth Sci Ctr, Denver, CO 80202 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 161, anno: 2000,
pagine: 50 - 56
SICI:
1073-449X(200001)161:1<50:AUINA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-VOLUME; SMOOTH-MUSCLE; SLEEP; BRONCHOCONSTRICTION; INFLAMMATION; RESISTANCE; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Irvin, CG Univ Vermont, Colchester Res Facil, 55A South Pk Dr, Colchester,VT 05446 USA Univ Vermont 55A South Pk Dr Colchester VT USA 05446 T 05446 USA
Citazione:
C.G. Irvin et al., "Airway-parenchyma uncoupling in nocturnal asthma", AM J R CRIT, 161(1), 2000, pp. 50-56

Abstract

Airway flow resistance is well known to be dependent upon lung volume. Therise in lung volume that occurs in asthma is therefore thought to be an important mechanism that defends airway patency. The purpose of the current study was to investigate the interdependence or mechanical coupling between airways and lung parenchyma during the inflammatory processes that occur inthe patient with nocturnal asthma, Five patients with documented nocturnalasthma were studied in both a vertical and a horizontal body plethysmograph. Lung volume was altered with continuous negative pressure as applied to the chest wall with a poncho cuirass in different postures and during sleep. We found during the awake phase that an increase in lung volume decreasedlower pulmonary resistance (Rip); however, within 30 min of sleep onset, functional residual capacity (FRC) fell and Rip rose more than would be expected for the fall in FRC. Restoring FRC to presleep values either at an early (half-hour) or a late (3-h) time point did not cause Rip to significantly fall. A second phase of the study showed that the loss of Rip dependence on lung volume was not due to the assumption of the supine posture. Indirect measurements of lung compliance were consistent with a stiffening of the lung, We conclude that with sleep there is an immediate uncoupling of the parenchyma to the airway, resulting in a loss of interdependence that persists throughout sleep and may contribute to the morbidity and mortality associated with nocturnal asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:52:24