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Titolo:
TNF-alpha stimulates alveolar liquid clearance during intestinal ischemia-reperfusion in rats
Autore:
Borjesson, A; Norlin, A; Wang, XD; Andersson, R; Folkesson, HG;
Indirizzi:
Univ Lund, Dept Anim Physiol, SE-22362 Lund, Sweden Univ Lund Lund Sweden SE-22362 Dept Anim Physiol, SE-22362 Lund, Sweden Univ Lund Hosp, Dept Surg, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 sp, Dept Surg, SE-22185 Lund, Sweden
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 1, volume: 278, anno: 2000,
pagine: L3 - L12
SICI:
1040-0605(200001)278:1<L3:TSALCD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; EPITHELIAL FLUID CLEARANCE; LUNG INJURY; SEPTIC SHOCK; MONOCLONAL-ANTIBODY; ANESTHETIZED SHEEP; PROTEIN CLEARANCE; PERMEABILITY; NEUTROPHIL; ENDOTOXIN;
Keywords:
tumor necrosis factor-alpha; endothelium; epithelium; lung; lung injury; pulmonary edema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Folkesson, HG Univ Lund, Dept Anim Physiol, Helgonavagen 3 B, SE-22362 Lund, Sweden Univ Lund Helgonavagen 3 B Lund Sweden SE-22362 und, Sweden
Citazione:
A. Borjesson et al., "TNF-alpha stimulates alveolar liquid clearance during intestinal ischemia-reperfusion in rats", AM J P-LUNG, 278(1), 2000, pp. L3-L12

Abstract

TNF-alpha stimulates alveolar liquid clearance during intestinal ischemia-reperfusion in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L3-L12, 2000.-Intestinal ischemia-reperfusion com monly occurs in critically ill patients and may lead to the development of remote organ injury, frequently involving the lungs. In the present study, alveolar liquid clearance was studied in ventilated, anesthetized rats subjected to 45 min of intestinal ischemia followed by 3 h of reperfusion. An isosmolar 5% albumin solution was instilled into the lungs, and alveolar liquid clearance was measured from the increase in alveolar protein concentration as water was reabsorbed over 45 min. Intestinal ischemia-reperfusion resulted in a 76% increase in alveolar liquid clearance compared with the control value (P < 0.05). The stimulated alveolar liquid clearance seen after intestinal ischemia-reperfusion was not inhibited by propranolol, indicating stimulation through a noncatecholamine-dependent pathway. Intestinal ischemia-reperfusion did not result in increased intracellular cAMP levels. Amiloride inhibited similar fractions in animals subjected to ischemia-reperfusion and control animals. Administration of a neutralizing polyclonal anti-tumor necrosis factor-cc antibodybefore induction of intestinal ischemia completely inhibited the increasedalveolar liquid clearance observed after intestinal ischemia-reperfusion. In conclusion, our results suggest that intestinal ischemia-reperfusion in rats leads to stimulation of alveolar liquid clearance and that this stimulation is mediated, at least in part, by a tumor necrosis factor-a-dependentmechanism.

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Documento generato il 06/04/20 alle ore 08:23:36