Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neuropeptide Y induces fasted pattern of duodenal motility via Y-2 receptors in conscious fed rats
Autore:
Fujimiya, M; Itoh, E; Kihara, N; Yamamoto, I; Fujimura, M; Inui, A;
Indirizzi:
Shiga Univ Med Sci, Dept Anat, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 t, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci, Dept Surg, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 g, Otsu, Shiga 5202192, Japan Ube Res Lab, Pharmaceut Res Dept, Ube, Yamaguchi 7558633, Japan Ube Res Lab Ube Yamaguchi Japan 7558633 pt, Ube, Yamaguchi 7558633, Japan Kobe Univ, Sch Med, Dept Internal Med 2, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 rnal Med 2, Kobe, Hyogo 6500017, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 1, volume: 278, anno: 2000,
pagine: G32 - G38
SICI:
0193-1857(200001)278:1<G32:NYIFPO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; DORSAL VAGAL COMPLEX; PANCREATIC-POLYPEPTIDE; PEPTIDE-YY; COLONIC MOTILITY; DOG; HORMONE; PYY;
Keywords:
intracerebroventricular neuropeptide Y receptors; peptide YY; pancreatic polypeptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimiya, M Shiga Univ Med Sci, Dept Anat, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 ga 5202192, Japan
Citazione:
M. Fujimiya et al., "Neuropeptide Y induces fasted pattern of duodenal motility via Y-2 receptors in conscious fed rats", AM J P-GAST, 278(1), 2000, pp. G32-G38

Abstract

Neuropeptide Y (NPY), a 36-amino acid peptide abundantly expressed in the brain, has been implicated in the regulation of feeding and visceral functions. The present study was designed to investigate whether or not NPY specifically regulates duodenal motility. The manometric method was used to measure duodenal motility in conscious, freely moving rats. The rat duodenum showed phasic contractions mimicking the migrating motor complex in the fasted state that were replaced by irregular contractions after the ingestion offood. NPY powerfully affected the contractile activity after intracerebroventricular (icv) administration, changing fed (postprandial) patter ns intophasic contractions characterized as fasted (interdigestive) patterns. This effect was mediated via receptors with pharmacological profiles similar to rat Y-2 and Y-4 receptors, although neither Y-1 nor Y-5 agonists had any effects on motility despite potent feeding-stimulatory effects. Immunoneutralization with anti-NPY antiserum administered icy abolished fasted patterns and induced fed-like motor activities. An icy dose of peptide YY produceda different effect from NPY, with increase in the motor activities of bothfed and fasted patterns. These results indicate that fasted and fed motor activities are regulated processes and that NPY induces fasted activity through Y-2, and possibly Y-4, receptors, which may represent an integrated mechanism linked to the onset of feeding behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:40:09