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Titolo:
Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder
Autore:
Du, LS; Bakish, D; Lapierre, YD; Ravindran, AV; Hrdina, PD;
Indirizzi:
Royal Ottawa Hosp, IMHR, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp Ottawa ON Canada K1Z 7K4 HR, Ottawa, ON K1Z 7K4, Canada Univ Ottawa, Ottawa, ON K1Z 7K4, Canada Univ Ottawa Ottawa ON Canada K1Z 7K4 v Ottawa, Ottawa, ON K1Z 7K4, Canada
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 96, anno: 2000,
pagine: 56 - 60
SICI:
0148-7299(20000207)96:1<56:AOPOS2>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMIPRAMINE BINDING-SITES; 5-HT2A RECEPTOR; T102C POLYMORPHISM; UP-REGULATION; SCHIZOPHRENIA; PLATELETS; CLOZAPINE; VICTIMS; IDENTIFICATION; PROMOTER;
Keywords:
suicidal ideation; serotonin; 5-HT2A receptor gene; major depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Du, LS Royal Ottawa Hosp, IMHR, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp 1145 Carling Ave Ottawa ON Canada K1Z 7K4 Canada
Citazione:
L.S. Du et al., "Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder", AM J MED G, 96(1), 2000, pp. 56-60

Abstract

There is evidence indicating that density of 5-HT2A receptors is altered in brain regions of depressed suicide victims and in platelets of suicidal subjects with major depression or schizophrenia. Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A receptor gene and schizophrenia. The present investigation tested the hypothesis that the observed changes in 5-HT2A receptor density in platelets of patients with major depression are a trait rather than state phenomenon and are associated with the 102 C allele in 5-HT2A receptor gene in a sampleof 120 patients with major depression and a group of 131 control subjects comparable with respect to age, sex, and ethnic background. The allele and genotype frequencies of 102T/C polymorphism in 5-HT2A receptor gene were compared between patients and control subjects and between suicidal and non-suicidal patient groups. The major finding of this study was a significant association between the 102 C allele in 5-HT2A receptor gene and major depression, chi(2) = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, chi(2) = 8.5, df = 1, P < 0.005. Furthermore, we found that patients with a 102 C/C genotype had a significantly higher mean HAMD item 3 score (indication of suicidal ideation) than T/C or T/T genotype patients, Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene isprimarily associated with suicidal ideation in patients with major depression. Arn. J, Med, Genet. (Neuropsychiatr, Genet.) 96:56-60, 2000, (C) 2000 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 09:00:18