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Titolo:
Low-grade astrocytoma - A retrospective analysis of 102 patients
Autore:
Kandil, A; Khafaga, Y; ElHusseiny, G; Allam, A; Jamshed, A; Schultz, H;
Indirizzi:
King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Sect Radiat Oncol, Riyadh 1121, Saudi Arabia King Faisal Specialist Hosp & Res Ctr Riyadh Saudi Arabia 1121 di Arabia
Titolo Testata:
ACTA ONCOLOGICA
fascicolo: 8, volume: 38, anno: 1999,
pagine: 1051 - 1056
SICI:
0284-186X(1999)38:8<1051:LA-ARA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM GLIOMAS; RADIATION-THERAPY; CEREBELLAR ASTROCYTOMA; CEREBRAL HEMISPHERES; CHILDREN; RADIOTHERAPY; TUMORS; IRRADIATION; EXPERIENCE; MANAGEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Schultz, H King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Sect Radiat Oncol, POB 3354,MBC 34, Riyadh 1121, Saudi Arabia King Faisal Specialist Hosp & Res Ctr POB 3354,MBC 34 Riyadh Saudi Arabia 1121
Citazione:
A. Kandil et al., "Low-grade astrocytoma - A retrospective analysis of 102 patients", ACTA ONCOL, 38(8), 1999, pp. 1051-1056

Abstract

One hundred and two patients (57 males, 45 females, median age 17 years) with histologically proven low-grade astrocytoma (grades I, II) treated between 1978 and 1994 were retrospectively analyzed at the King Faisal Specialist Hospital si Research Center. Microscopic investigation showed 50 patients (48%) with grade I tumors as opposed to 52 patients (52%) with grade II tumors. Fifteen patients (15%) had complete surgical excision, 55 (52%) had partial excision and 32 (31%) had biopsy only; 68 patients (66%) received external radiotherapy with a median dose of 54 Gy (range 45-68.5 Gy). With amedian follow-up of 3.3 years, the 5 and 10 years' overall actuarial survival rates were 78% and 62%, respectively while the progression-free survival rates at 5 and 10 years were 69% and 35%, respectively. Age and performance status were significant prognostic factors in terms of overall survival on univariate (p = 0.05 and 0.05, respectively) and multivariate analysis (p = 0.005 and 0.006, respectively).

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Documento generato il 25/01/20 alle ore 06:31:07