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Titolo:
HIGH-PERFORMANCE ION CHROMATOGRAPHY APPLIED TO FREE-RADICAL MECHANISMS IN DRUG DESIGN - THE PROBLEM OF ION ANALYSIS AT HIGH IONIC STRENGTHS
Autore:
EVERETT SA; DENNIS MF; PATEL KB; WARDMAN P; STRATFORD MRL;
Indirizzi:
MT VERNON HOSP,CANC RES TRUST,GRAY LAB,POB 100 NORTHWOOD HA6 2JR MIDDX ENGLAND
Titolo Testata:
Journal of chromatography
fascicolo: 1-2, volume: 770, anno: 1997,
pagine: 273 - 279
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXY-L-ARGININE; RECOMBINANT INTERLEUKIN-2 RIL-2; ADVANCED MALIGNANT-MELANOMA; FLAVONE ACETIC-ACID; NITRIC-OXIDE; FLAVONE-8-ACETIC ACID; XANTHENONE-4-ACETIC ACID; RADIATION-CHEMISTRY; OXIDATION; AUTOXIDATION;
Keywords:
RADICALS; PHARMACEUTICAL ANALYSIS; RADIATION CHEMISTRY; DRUGS; HYDROXYARGININE; HYDROXYGUANIDINE; PERTHIOL DRUGS; ANIONS; NITRIC OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Everett et al., "HIGH-PERFORMANCE ION CHROMATOGRAPHY APPLIED TO FREE-RADICAL MECHANISMS IN DRUG DESIGN - THE PROBLEM OF ION ANALYSIS AT HIGH IONIC STRENGTHS", Journal of chromatography, 770(1-2), 1997, pp. 273-279

Abstract

Putative free-radical intermediates in drug action can be studied by radiolysis of model systems containing low concentrations of drug and much higher concentrations of other solutes to scavenge the primary water radicals and convert them into appropriate oxidants or reductants. The need to employ high ionic solute concentrations (typically >10 mmol dm(-3)) represents a challenge for the high-performance ion chromatographic detection of drug-derived ions (typically, <50 mu mol dm(-3)). Constraints on the chromatographic method chosen are illustrated with examples of the application of high-performance ion chromatography (HPIC) to radiation chemistry studies in the oxidative decarboxylation of the anti-tumour drugs flavone-8- and xanthenone-4-acetic acids and structurally related aromatic carboxylic acids (GO, in the form of CO32-), the oxidative denitrification of nitric oxide precursor molecules(NO. in the form of NO2-/NO3-) and the generation of SO42- from novelthiol-based (perthiol) drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:20:30