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Titolo:
Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats
Autore:
Tauboll, E; Isojarvi, JIT; Harbo, HF; Pakarinen, AJ; Gjerstad, L;
Indirizzi:
Univ Oslo, Rikshosp, Dept Neurol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Rikshosp, Dept Neurol, N-0027 Oslo, Norway Univ Oulu, Dept Neurol, Oulu 90220, Finland Univ Oulu Oulu Finland 90220Univ Oulu, Dept Neurol, Oulu 90220, Finland Univ Oulu, Dept Clin Chem, Oulu 90220, Finland Univ Oulu Oulu Finland 90220 v Oulu, Dept Clin Chem, Oulu 90220, Finland
Titolo Testata:
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
fascicolo: 8, volume: 8, anno: 1999,
pagine: 490 - 493
SICI:
1059-1311(199912)8:8<490:LVTICI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE ENDOCRINE DISORDERS; WOMEN; EPILEPSY;
Keywords:
valproate; estrogen; testosterone; polycystic ovaries; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Tauboll, E Univ Oslo, Rikshosp, Dept Neurol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Dept Neurol, N-0027 Oslo, Norway
Citazione:
E. Tauboll et al., "Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats", SEIZURE-E J, 8(8), 1999, pp. 490-493

Abstract

Long-term valproate treatment is associated with polycystic ovaries and endocrine disorders in women with epilepsy. The mechanisms responsible for these effects are unknown, but both the epilepsy itself and the drug per se may be of importance. The aim of this study was to investigate possible effects of the dug on gonadal structure and function in animals with no epileptic disorders. Three groups, each of 15 female Wistar rats, were fed perorally with a valproate mixture (50 mg/kg or 200 mg/kg) or central solution once daily for 90 days, giving mean valproate concentrations within the normalhuman range. A significant, 20% increase in ovary weight was found in bothlow- (P = 0.027) and high- (P < 0.001) dose animals together with a significantly increased number of ovarian follicular cysts. Mean serum testosterone concentration was significantly reduced in both low- and high-dose animals. There was a non-significant trend towards reduced estrogen levels, while progesterone levels were unchanged. Even if the hormonal changes are somewhat different from those in humans, the findings demonstrate that changes in gonadal structure and endocrine function also occur in intact animals indicating a drug-specific effect. Our findings encourages further studies using animal models to elucidate possible mechanisms involved in the:endocrine side-effects of antiepileptic drugs. (C) 1999 BEA Trading Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:51:27