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Titolo:
Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations
Autore:
Heinz, A; Weingartner, H; George, D; Hommer, D; Wolkowitz, OM; Linnoila, M;
Indirizzi:
Univ Heidelberg, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-68159 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68159 Med, D-68159 Mannheim, Germany Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA NIAAA, Bethesda, MD 20892 USA NIAAA Bethesda MD USA 20892NIAAA, Bethesda, MD 20892 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2, volume: 89, anno: 1999,
pagine: 97 - 106
SICI:
0165-1781(199912)89:2<97:SODIAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY CONTROL SUBJECTS; CEREBROSPINAL-FLUID; PANIC DISORDER; 5-HYDROXYINDOLEACETIC ACID; MAJOR DEPRESSION; CORTISOL; WITHDRAWAL; SEROTONIN; DHEA; RAT;
Keywords:
depression; alcoholism; neurosteroids; detoxification stress; cortisol; DHEA-S;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Heinz, A Univ Heidelberg, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, J5, D-68159 Mannheim, Germany Univ Heidelberg J5 Mannheim Germany D-68159 59 Mannheim, Germany
Citazione:
A. Heinz et al., "Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations", PSYCHIAT R, 89(2), 1999, pp. 97-106

Abstract

Depressed mood increases the relapse risk of abstinent alcoholics; its neurobiological correlates may include reduced serotonin and norepinephrine turnover rates and increased cortisol concentrations during detoxification stress. Neurosteroids such as dehydroepiandrosterone and its sulfate (DHEA and DHEA-S) may antagonize cortisol action and may have mood-elevating effects on their own. We measured severity of depression with Beck's Depression Inventory (BDI) and Hamilton's Depression Rating Scale (HDRS), plasma concentrations of cortisol, DHEA and DHEA-S, and CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and the dopamine metabolite homovanillic acid (HVA) in 21 abstinent alcoholics after 4 weeks of abstinence and in 11 age-matched healthy control subjects. Only CSF MHPG concentrations were reduced in alcoholics compared to control subjects (41.4 +/- 6.6 vs. 53.3 +- 8.6 pmol/ml). Self-rated depression was significantly correlated with CSF MHPG (Spearman's R = + 0.57, P < 0.01), CSF 5-HLAA (R = + 0.51, P < 0.05) and plasma cortisol concentrations (R = + 0.50, P < 0.05). Negative correlations were found between DHEA-S concentrations and both self-rated depression (R = -0.45, P < 0.05) and observer-rated depression (R = - 0.55, P < 0.05). The ratio of DHEA-S to cortisol serum concentrations was alsonegatively correlated with depression (BDI: R = -0.55, P < 0.01; HDRS: R =- 0.63, P < 0.005). Anxiety (Spielberger's State Anxiety Scale) was only associated with CSF MHPG concentrations (R = + 0.58, P < 0.01). Our findingspoint to the importance of noradrenergic dysfunction in the pathogenesis of depression among abstinent alcoholics and indicate that their mood statesmay also be modulated by a low DHEA-S to cortisol ratio, hypothetically indicative of IOW stress protection capacities. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 19/09/20 alle ore 09:27:07