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Titolo:
Super-motifs and evolution of tandem leucine-rich repeats within the smallproteoglycans - Biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
Autore:
Matsushima, N; Ohyanagi, T; Tanaka, T; Kretsinger, RH;
Indirizzi:
Sapporo Med Univ, Sch Hlth Sci, Sapporo, Hokkaido 0608556, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608556 , Hokkaido 0608556, Japan Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Sapporo, Hokkaido, Japan Hokkaido Univ Sapporo Hokkaido Japan Biol Sci, Sapporo, Hokkaido, Japan Univ Virginia, Dept Biol, Charlottesville, VA USA Univ Virginia Charlottesville VA USA Dept Biol, Charlottesville, VA USA
Titolo Testata:
PROTEINS-STRUCTURE FUNCTION AND GENETICS
fascicolo: 2, volume: 38, anno: 2000,
pagine: 210 - 225
SICI:
0887-3585(20000201)38:2<210:SAEOTL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERMATAN SULFATE PROTEOGLYCAN; PLACENTAL RIBONUCLEASE INHIBITOR; BINDING-PROTEIN COMPLEX; EXPRESSION SITE ENCODES; COMPLETE CDNA CLONING; AMINO-ACID-SEQUENCE; MOLECULAR-CLONING; CORE PROTEIN; CHROMOSOMAL LOCALIZATION; ARTICULAR-CARTILAGE;
Keywords:
tandem repeat; super-repeat; proteoglycan I; proteoglycan II; proline arginine-rich and leucine-rich protein; PG-Lb; chondroadherin; gene duplication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Matsushima, N Sapporo Med Univ, Sch Hlth Sci, Sapporo, Hokkaido 0608556, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608556 8556, Japan
Citazione:
N. Matsushima et al., "Super-motifs and evolution of tandem leucine-rich repeats within the smallproteoglycans - Biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin", PROTEINS, 38(2), 2000, pp. 210-225

Abstract

Leucine-rich repeats (LRRs) with 20-30 amino acids in unit length are present in many proteins from prokaryotes to eukaryotes, The LRR-containing proteins include a family of nine small proteoglycans, forming three distinct subfamilies: class I contains biglycan/PG-I and decorin/PG-II; class II: lumican, fibromodulin, PRELP, keratocan, and osteoadherin; and class III: epiphycan/PG-Lb and osteoglycin or osteoinductive factor. Comparative sequenceanalysis of the 34 available protein sequences reveals that these proteoglycans have two types of LRRs, which we call S and T. The type S LRR is 21 residues long and has the consensus sequence of xxaPzxLPxxLxLxxNxI. The typeT LRR has 26 residues; its consensus sequence is zzxxaxxxxFxxaxxLxxLxLxxNxL.. In both "x" indicates variable residue; "z" is frequently a gap; "a" isVal, Leu, or ne; and I is ne or Leu. These type S and T LRRs are ordered into two super-motifs-STT with about 73 residues in classes I and II and ST with about 47 residues in class III. The 12 LRRs in the small proteoglycansof I and II are best represented as (STT)(4); the seven LRRs of class III as (ST)T(ST)(2). Our analyses indicate that classes I/II and III evolved along different paths after the establishment of the precursor ST, and classes I and II also diverged after the establishment of the precursor (STT)(4). Proteins 2000;38:210-225. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:42:09