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Titolo:
Virus phenotype switching and disease progression in HIV-1 infection
Autore:
Callaway, DS; Ribeiro, RM; Nowak, MA;
Indirizzi:
Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3PS, England Univ Oxford Oxford England OX1 3PS l Infect Dis, Oxford OX1 3PS, England Inst Adv Study, Princeton, NJ 08540 USA Inst Adv Study Princeton NJ USA 08540 Adv Study, Princeton, NJ 08540 USA
Titolo Testata:
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1437, volume: 266, anno: 1999,
pagine: 2523 - 2530
SICI:
0962-8452(199912)266:1437<2523:VPSADP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; DYNAMICS IN-VIVO; TYPE-1 INFECTION; IMMUNE-RESPONSES; VIRAL PHENOTYPE; VARIANTS; THERAPY; CELLS; LOAD; AIDS;
Keywords:
syncytium-inducing; non-syncytium-inducing; phenotype switch; HIV-1; mathematical model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Ribeiro, RM Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, S Parks Rd, Oxford OX1 3PS, England Univ Oxford S Parks Rd Oxford England OX1 3PS X1 3PS, England
Citazione:
D.S. Callaway et al., "Virus phenotype switching and disease progression in HIV-1 infection", P ROY SOC B, 266(1437), 1999, pp. 2523-2530

Abstract

One of the phenotypic distinctions between different strains of human immunodeficiency virus type 1 (HIV-1) has to do with the ability to cause target cells to form large multinucleate bodies known as syncytia. There are twophenotypes according to this characterization: syncytium-inducing (SI) andnon-syncytium-inducing (NSI). NSI strains are usually present throughout infection, while SI strains are typically seen at the beginning of the infection and near the onset of AIDS. The late emergence of SI strains is referred to as phenotype switching. In this paper we analyse the factors that lead to phenotype switching and contribute to the dynamics of disease progression. We show that a strong immune system selects for NSI strains while a weak immune system favours SI strains. The model explicitly account-a for thefact that CD4+ cells are both targets of HIV infection and crucial for activating immune responses against HIV. In such a model, SI strains can emerge after a long and variable period of NSI dominated infection. Furthermore,versions of the model which do not explicitly account for HIV-specific, activated CD4+ cells do not exhibit phenotype switching, emphasizing the critical importance of this pool of cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 14:26:38