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Titolo:
Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes
Autore:
Fresta, M; Puglisi, G;
Indirizzi:
Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 harmaceut Sci, I-95125 Catania, Italy
Titolo Testata:
PHARMACEUTICAL RESEARCH
fascicolo: 12, volume: 16, anno: 1999,
pagine: 1843 - 1849
SICI:
0724-8741(199912)16:12<1843:ROMPIC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG CIRCULATING LIPOSOMES; DELAYED NEURONAL DEATH; BLOOD-BRAIN-BARRIER; POSTISCHEMIC REPERFUSION; CYTIDINE-5'-DIPHOSPHATE CHOLINE; RAT; GERBIL; CITICOLINE; EFFICIENCY; DAMAGE;
Keywords:
cerebral ischemia; ischemic maturation; CDP-choline loaded liposomes; brain lipoperoxidation; liposomal brain delivery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fresta, M Univ Catania, Dept Pharmaceut Sci, Viale Andrea Doria 6, I-95125Catania, Italy Univ Catania Viale Andrea Doria 6 Catania Italy I-95125 , Italy
Citazione:
M. Fresta e G. Puglisi, "Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes", PHARM RES, 16(12), 1999, pp. 1843-1849

Abstract

Purpose. Cerebral ischemia represents a serious therapeutic challenge. we investigated the therapeutic efficacy of CDP-choline-loaded liposomes against cerebral ischemia. The determination of post-ischemic brain recovery by EEG analysis was carried out to evaluate the effect of CDP-choline-loaded liposomes with respect to the free drug on the maturation of ischemic injury. Methods. Long-circulating unilamellar liposomes were prepared by a freeze and thaw procedure followed by an extrusion through polycarbonate membranes. Wistar rats were ischemized by bilateral clamping of the common carotid arteries. Free or liposomally entrapped drug was administered (20 mg/kg) just after ischemia and thereafter once a day for six days. Post-ischemic survival, neuronal membrane peroxidation and brain recovery (EEG analysis) wereevaluated. Results. The post-ischemic reperfused rats treated with CDP-choline-loadedliposomes showed a higher survival rate than animals treated with the freedrug. The delayed cerebral neurodegenerative injury due to an ischemic event, referred to as maturation phenomenon, was substantially reduced with the administration of the liposomal formulation. The liposomal carrier showeda marked protection against lipoperoxidative damage. Conclusions. Liposomes ensured a rapid recovery of the damaged membranous structure of the neuronal cells, allowing a significant improvement of brain functionality. The reduction of the maturation phenomenon may probably beof particular importance in humans, where a fundamental problem is the quality of life after an ischemic event.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:29:23