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Titolo:
Antagonistic effects of [Nphe(1)]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor
Autore:
Hashimoto, Y; Calo, G; Guerrini, R; Smith, G; Lambert, DG;
Indirizzi:
Leicester Royal Infirm, Univ Dept Anaesthesia & Pain Management, LeicesterLE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE15WW WW, Leics, England Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 harmacol Sect, I-44100 Ferrara, Italy Univ Ferrara, Dept Pharmaceut Sci, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 harmaceut Sci, I-44100 Ferrara, Italy
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 278, anno: 2000,
pagine: 109 - 112
SICI:
0304-3940(20000107)278:1-2<109:AEO[ON>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS IN-VITRO; RAT SPINAL-CORD; ORL1 RECEPTOR; FQ RECEPTOR; AGONIST; CHANNEL;
Keywords:
nociceptin/orphanin FQ; antagonist; [Nphe1]nociceptin(1-13)NH2; cAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lambert, DG Leicester Royal Infirm, Univ Dept Anaesthesia & Pain Management, LeicesterLE1 5WW, Leics, England Leicester Royal Infirm Leicester LeicsEngland LE1 5WW ngland
Citazione:
Y. Hashimoto et al., "Antagonistic effects of [Nphe(1)]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor", NEUROSCI L, 278(1-2), 2000, pp. 109-112

Abstract

Nociceptin/orphanin FQ (NC) is the endogenous ligand for the nociceptin receptor (NCR) which is negatively coupled to adenylyl cyclase to inhibit theformation of cAMP. In this study we describe the inhibitory action of the novel NC analogue, [Nphe(1)]nociceptin(1-13)NH2 on cAMP formation in Chinese hamster ovary cells expressing the human NCR. NC, NC(1-13)NH2, the pseudopeptides [Phe(1)psi(CH2-NH)Gly(2)]NC(1-17)NH2 and [Phe(1)psi(CH2-NH)Gly(2)]NC(1-13)NH2, the hexapeptide, acetyl-Arg-Tyr-Tyr-Arg-Trp-Lys-N Hp and buprenorphine all produced a concentration dependent inhibition of forskolin stimulated cAMP formation. This inhibition was competitively reversed by [Nphe(1)] NC(1-13)NH2 with essentially identical pA(2) values (6.12-6.48). [Nphe(1)]NC(1-l3)NH2 showed per se a negligible residual agonist activity (alpha< 0.15). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:00:30