Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M-1 receptors
Autore:
Rouse, ST; Hamilton, SE; Potter, LT; Nathanson, NM; Conn, PJ;
Indirizzi:
Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ed, Dept Pharmacol, Atlanta, GA 30322 USA Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA Univ Miami, Dept Pharmacol, Miami, FL 33101 USA Univ Miami Miami FL USA 33101 Miami, Dept Pharmacol, Miami, FL 33101 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 278, anno: 2000,
pagine: 61 - 64
SICI:
0304-3940(20000107)278:1-2<61:MMOPCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SYMPATHETIC NEURONS; CHOLINERGIC INNERVATION; SUPPRESSION; INHIBITION; ANTAGONIST; CURRENTS; SUBTYPES; PROTEINS;
Keywords:
muscarinic; hippocampus; M-1-toxin; M-1-knockout; afterhyperpolarization current; M current;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Conn, PJ Emory Univ, Sch Med, Dept Pharmacol, 1510 Clifton Rd, Atlanta, GA30322 USA Emory Univ 1510 Clifton Rd Atlanta GA USA 30322 nta, GA 30322 USA
Citazione:
S.T. Rouse et al., "Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M-1 receptors", NEUROSCI L, 278(1-2), 2000, pp. 61-64

Abstract

Activation of muscarinic acetylcholine (ACh) receptors (mAChRs) increases excitability of pyramidal cells by inhibiting several K+ conductances, including the after-hyperpolarization current (I-ahp), the M-current (I-m), anda leak K+ conductance (I-leak) Based on pharmacological evidence and the abundant localization of M-1 receptors in pyramidal cells, it has been assumed that the M-1 receptor is responsible for mediating these effects. However, given the poor selectivity of the pharmacological agents used to characterize these mAChR responses, rigorous characterization of the receptor subtypes that mediate these actions has not been possible. Surprisingly, patch clamp recording from CA1 pyramidal cells in M-1 knockout mice revealed no significant difference in the degree of inhibition of I-ahp,I- I-m, or I-leak by the mAChR agonist, carbachol (CCh), as compared with wildtype controls. In addition, the M-1-toxin was not able to block CCh's inhibition of the I-ahp, I-m, or I-leak. These data demonstrate that the M-1 receptor is not involved in increasing CA1 pyramidal cell excitability by mediating ACh effects on these K+ conductances. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:25:47